エタノール含有ゲル型擦式手指消毒剤の臨床現場における手指消毒効果の検討

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For the disinfection of the hands, a basic measure used in the prevention of nosocomial infections, the existing guidelines recommend the use of alcohol-based hand rub agents, such as those drawn up by CDC (USA). Since such agents have shortcomings, in recent years, gel-form disinfectants have been developed to overcome them and have started to be used for disinfection. However, some investigators have reported that the disinfection efficacy of gel-form agents is lower than that of liquid-based agents and so we conducted the present study to compare these two types of agent in this regard using the palm stamp method. Nine subjects used gel-form disinfectants (hand rub agents containing 76.9-81.4 v/v% ethanol) and another nine subjects used a liquid-form disinfectant (hand rub agents containing 0.2 v/v% benzalkonium chloride and 83 v/v% ethanol). In the gel agent group, the average bacterial count decreased from 383.0±433.9 (mean±SD) before disinfection to 19.1±16.0 after disinfection. In the liquid agent group, the average bacterial count decreased from 609.3±789.7 to 84.7±186.5. The bacterial removal rate was 91.6%±8.6 in the gel agent group and 85.4%±12.3 in the liquid agent group. After disinfection, no MRSA, enterococci or Gram-negative rods were evident in either group. These results demonstrate that gel agents achieve adequate bacterial removal from hands immediately after use and that their disinfecting effect is satisfactory from a clinical point of view. They also indicate that gel-form disinfectants are a promising means of disinfecting the hands of healthcare professionals in the clinical setting.
日本医療薬学会の論文
2007-01-10

エタノール含有ゲル型擦式手指消毒剤の臨床現場における手指消毒効果の検討

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