牛のコセ又はワヒ病に関する研究 : V.原因論補充

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Since 1952 we have studied on Kose disease in cattle. In I and II reports we stated that this disease is a dermatitis caused by microfilariae of Onchocerca gutturosa from the parasitological, clinical pathological points of view. In III and IV reports we have strengthened this microfilarial theory on the etiology by the therapeutical experiment. This time we have carried out the supplementary investigations to strengthen our etiological theory. 1. NAKAMURA and ISHIHARA reported that Kasen disease, a disease similar to this disease, is an allergic disease due to the bite of the bloodsucking insects. Necessity compelled us to investigate whether the cause of Kose disease relates or not to the bite of bloodsucking insects such as mosquito, black-fly and sandfly. According to the results obtained, there are a few occurrences this disease in winter when insects do not appear. Having bled two cows advancing in this disease in an insect-controllroom surrounded with the wire-netting for 15 days, the disease continued advancing and did not heal until the end. It seems this fact shows there is no relation between the bloodsucking insect and the cause of Kose disease. 2. From the necessity of the comparative study on the etiology of Kose and Kasen diseases we have alse investigated etiologically on Kasen disease. It has been known that there are two types in Kasen disease. One type appears like Kasen disease described by NAKAMURA and ISHIHARA as a disease caused by the bite of blood-sucking insects and the other type closely resembles Kose disease, its causal agent seeming to be microfilariae of Onchocerca cervicalis. By this fact it seems that our microfilarial theory on the etilogy of Kose disease is made stronger. 3. Parasitizing of O. gutturosa is seen not only in diseased cattle but also in healthy cattle. If microfilariae of this worm are the causal agent of this disease, it may become a question why all cattle parasitized with this microfilariae are not attacked by this disease. To solve this question we have tried the allergic consideration on pathogensis of this disease. This disease especially occurs only in a part of cattle parasirized with microfilariae, the itchiness like allergy is present, pathohistological change of the skin is an inflammatory change like the allergic change of the blood vessel and the connective tissue. The allergic skin-reaction made with the antigen prepared with the adults of this worm is possitive generally both in diseased and healthy cattle parasitized with this worm. But this positive reaction shows relatively stronger tendency in diseased cattle than in healthy cattle. Next, by dosing venacalsim B_6,a case of antiallergic madicines, to diseased cattle, an itching sense disappears during dosing, the disease lightening temporarily. The above described results may suggest that this disease is an allergic disease caused by microfilariae of Onchocerca gutturosa.
鹿児島大学の論文
1962-03-25

牛のコセ又はワヒ病に関する研究 : V.原因論補充

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