Effects of Genistein, an Isoflavone, on Pregnancy Outcome and Organ Weights of Pregnant and Lactating Rats and Development of Their Suckling Pups
スポンサーリンク
概要
- 論文の詳細を見る
There is a general agreement that isoflavones can be beneficial to health in adults. However, isoflavones are well known as endocrine-disrupting chemicals. It should be considered that soy foods might adversely affect the reproductive system and infants. The aim of this study was to evaluate the effects of genistein, an isoflavone, on dams and their offspring. Maternal rats were fed diets containing genistein at levels of 0 and 0.5g/kg diet from pregnancy day 5 to postnatal day 13. No effects of genistein on the delivery, anogenital distance, reproductive organ weight, and body weight of the infants at birth were observed. There were no consistent effects on suckling pups after continuous genistein exposure during their fetal and suckling stages through their mothers, and there was no difference in effects according to the periods of exposure during pregnancy and lactation. We also observed no significant effect on the growth of offspring after weaning. Moreover, while we observed that the serum concentration of triiodothyronine (T_3) in dams decreased, the result was a tendency, not a significant decrease. Our study suggested that maternal ingestion of genistein might have not induced serious adverse effects on dams, fetuses, infants or offspring during growth. However, the results indicated in many papers suggest the necessity of further study on the safety of genistein.
- 日本ビタミン学会の論文
著者
-
NAKASHIMA Yoko
Department of Human Nutrition, Seitoku University
-
ISHIMI YOSHIKO
Division of Food Science, National Institute of Health and Nutrition
-
Ishimi Yoshiko
Division Of Applied Food Research National Institute Of Health And Nutrition
-
Ishimi Yoshiko
国立健康・栄養研究所 食品機能研究部
-
Ikegami Sachie
Department Of Home Economics Otsuma Women's University
-
Tousen Yuko
Department of Human Life and Culture, Seitoku University
-
UMEKI Miki
Faculty of Education and Welfare Science, Oita University
-
Umeki Miki
Faculty Of Education And Welfare Science Oita University
-
Tousen Yuko
Department Of Human Life And Culture Seitoku University
-
Nakashima Yoko
Dep. Of Human Nutrition Seitoku Univ.
-
Nakashima Yoko
Department Of Human Life And Culture Seitoku University
-
ISHIMI Yoshiko
Department of Food Science, The National Institute of Health and Nutrition
-
ISHIMI Yoshiko
Department of Food Function and Labeling, National Institute of Health and Nutrition
-
IKEGAMI Sachie
Department of Food Science, The National Institute of Health and Nutrition
関連論文
- Exposure to Dams' Low-Fat High-Carbohydrate Diet during Pregnancy and Lactation Establishes a Preference for Fat by Their Offspring
- Effect of Plant- and Fish-Oil Derived u-3 Polyunsaturated Fatty Acids on Counteraction of n-3 Fatty Acid Shortage in Adult Rats Fed a Lard Diet
- Preferential Fat Intake of Pups Nursed by Dams Fed Low Fat Diet during Pregnancy and Lactation Is Higher than That of Pups Nursed by Dams Fed Control Diet and High Fat Diet
- Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice.
- Puerariase radix prevents bone loss in ovariectomized mice.
- Puerariae radix prevents bone loss in ovariectomized mice
- Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats
- Soybean isoflavones preserve bone mass in hindlimb-unloaded mice
- Effects of Spirulina, a Blue-Green Alga, on Bone Metabolism in Ovariectomized Rats and Hindlimb-Unloaded Mice
- Possible Adverse Effects of Soy Isoflavone Mixture on Pregnant and Lactating Rats and their Suckling Pups
- Effects of Genistein, an Isoflavone, on Pregnancy Outcome and Organ Weights of Pregnant and Lactating Rats and Development of Their Suckling Pups
- Ovariectomy in Mice Decreases Lipid Metabolism-Related Gene Expression in Adipose Tissue and Skeletal Muscle with Increased Body Fat
- Hexachlorobenzene and Pentachlorobenzene Accumulated during Pregnancy is Transferred to Pups at the Accumulation Ratio in Dams
- Ratio of High-Fat Diet Intake of Pups Nursed by Dams Fed Combination Diet Was Lower Than That of Pups Nursed by Dams Fed High-Fat or Low-Fat Diet
- Consumption of a High-Fat Diet Containing Lard during the Growth Period in Rats Predisposes Them to Favorably Respond to the Diet in Later Life
- Hypoglycemic and Hypolipidemic Effects of Hesperidin and Cyclodextrin-Clathrated Hesperetin in Goto-Kakizaki Rats with Type 2 Diabetes
- Rats Allowed to Self-Select Zinc-Deficient Lard and Fish-Oil Diets Did Not Develop a Preference for Fish-Oil Diet
- Fish-Oil High-Fat Diet Intake of Dams after Day 5 of Pregnancy and during Lactation Guards against Excessive Fat Consumption of Their Weaning Pups
- Vitamin A and Carotenoids Stimulate Differentiation of Mouse Osteoblastic Cells
- Rats Allowed to Self-Select Zinc-Deficient Lard and Fish-Oil Diets Did Not Develop a Preference for Fish-Oil Diet
- Time Reduction of Vitamin B6 and Inositol Assay by Using Lyophilized Saccharomyces cerevisiae ATCC 9080
- Dietary Reference Intakes for Japanese 2010: Macrominerals
- Effect of long-term voluntary exercise and energy restriction on bone mineral density in mature female rats