Hexachlorobenzene and Pentachlorobenzene Accumulated during Pregnancy is Transferred to Pups at the Accumulation Ratio in Dams

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概要

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• Hexachlorobenzene (HCB) and pentachlorobenzene (PECB) were used to clarify how the rate at which lipophilic environmental pollutants are metabolized will affect their transfer to pups. In this study, the ratio of PECB/HCB transference to fetuses and suckling pups was investigated in rats fed a diet containing HCB (35.1nmol/100g diet) and PECB (351nmol/100g diet). The amounts of HCB and PECB transferred to fetuses were 0.44% and 0.15% of the amounts consumed by their dams, respectively, and the PECB/HCB concentration ratio in fetuses was 3.4. In pregnant rats on the day before parturition, the PECB concentrations in organs and fat tissue were 3 to 4 times higher than those of HCB. After parturition, PECB rapidly disappeared from the body of nursing rats during the lactation period, especially when compared with HCB. On day 2 after birth, HCB and PECB concentrations in the stomach contents of suckling pups were highest, and the PECB concentration was 3.5 times higher than that of HCB. HCB in the stomach contents decreased gradually (T_<1/2>=5.7 d) and PECB decreased rapidly (T_<1/2>=2.8 d) during the 15 d after birth. These findings indicate that the PECB/HCB transferred to fetuses and suckling pups was the same ratio found in the blood of their dams.

• 公益社団法人日本薬学会の論文
• 2000-04-01

著者

• NAKASHIMA Yoko

  Department of Human Nutrition, Seitoku University

• Ikegami Sachie

  Department Of Home Economics Otsuma Women's University

• Nakashima Yoko

  Dep. Of Human Nutrition Seitoku Univ.

• Nakashima Yoko

  Department Of Human Life And Culture Seitoku University

• IKEGAMI Sachie

  Department of Food Science, The National Institute of Health and Nutrition

関連論文

• Exposure to Dams' Low-Fat High-Carbohydrate Diet during Pregnancy and Lactation Establishes a Preference for Fat by Their Offspring
• Effect of Plant- and Fish-Oil Derived u-3 Polyunsaturated Fatty Acids on Counteraction of n-3 Fatty Acid Shortage in Adult Rats Fed a Lard Diet
• Preferential Fat Intake of Pups Nursed by Dams Fed Low Fat Diet during Pregnancy and Lactation Is Higher than That of Pups Nursed by Dams Fed Control Diet and High Fat Diet
• Possible Adverse Effects of Soy Isoflavone Mixture on Pregnant and Lactating Rats and their Suckling Pups
• Effects of Genistein, an Isoflavone, on Pregnancy Outcome and Organ Weights of Pregnant and Lactating Rats and Development of Their Suckling Pups
• Hexachlorobenzene and Pentachlorobenzene Accumulated during Pregnancy is Transferred to Pups at the Accumulation Ratio in Dams
• Ratio of High-Fat Diet Intake of Pups Nursed by Dams Fed Combination Diet Was Lower Than That of Pups Nursed by Dams Fed High-Fat or Low-Fat Diet
• Consumption of a High-Fat Diet Containing Lard during the Growth Period in Rats Predisposes Them to Favorably Respond to the Diet in Later Life
• Rats Allowed to Self-Select Zinc-Deficient Lard and Fish-Oil Diets Did Not Develop a Preference for Fish-Oil Diet
• Fish-Oil High-Fat Diet Intake of Dams after Day 5 of Pregnancy and during Lactation Guards against Excessive Fat Consumption of Their Weaning Pups
• Vitamin A and Carotenoids Stimulate Differentiation of Mouse Osteoblastic Cells
• Rats Allowed to Self-Select Zinc-Deficient Lard and Fish-Oil Diets Did Not Develop a Preference for Fish-Oil Diet

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