Intra-Individual Variability of High-Sensitivity C-Reactive Protein : Age-Related Variation Over Time in Japanese Subjects(CLINICAL INVESTIGATION)

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概要

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• Background Prospective studies have demonstrated a direct association between the baseline level of high-sensitivity C-reactive protein (hsCRP) and the risk of developing cardiovascular disease. The potential for hsCRP variability during the follow-up interval is of great interest, so the repeatability of measurements of hsCRP in men and women, and in different age groups, was investigated in the present study. Methods and Results The measurement of hsCRP was performed in 899 male and 780 female Japanese civil servants aged 18-60 years in the spring of 2004 and 2005. Within-subject repeatability and intra-class correlation coefficient of reliability were used to characterize the variation in measurements. Error of the measurement process was negligible, as the analytical variance was 0.0003 [ln(mg/L)] [ln(mg/L)] with a reliability coefficient of 0.997. In contrast, the within-subject variation of hsCRP was considerable with a reliability coefficient of 0.61 in both sexes and repeatability coefficients of 5.25 and 5.38 in men and women, respectively. The variation differed with age, especially in women, as less variation was observed in subjects over 40 years of age during the follow-up interval. Conclusions The results suggest that a single measurement of hsCRP is subject to considerable but equal withinsubject variation over time in men and women, and this variation differs among the age groups, which may affect the risk assessment of hsCRP in association with future cardiovascular events.

• 社団法人日本循環器学会の論文
• 2006-04-20

著者

• KAGAMIMORI SADANOBU

  Department of Welfare Promotion and Epidemiology, Toyama Medical and Pharmaceutical University

• Nasermoaddeli Ali

  Department of Epidemiology and Public Health, Kanazawa Medical University

• Nasermoaddeli Ali

  Department Of Welfare Promotion And Epidemiology Graduate School Of Medical Sciences University Of T

• ナセルモアデリ アリ

  富山医科薬科大学保健医学教室

• Nasermoaddeli Ali

  Department Of Epidemiology And Public Health Kanazawa Medical University

• Kagamimori S

  Department Of Welfare Promotion And Epidemiology Faculty Of Medicine University Of Toyama

• Kagamimori Sadanobu

  聖マリアンナ医科大学 予防医学

• Kagamimori Sadanobu

  Department Of Community Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical University

• Suka Machi

  Department Of Preventive Medicine St Marianna University School Of Medicine

• SEKINE Michikazu

  Department of Welfare Promotion and Epidemiology, Toyama Medical and Pharmaceutical University

• Kagamimori Sadanobu

  Department Of Welfare Promotion And Epidemiology Graduate School Of Medicine And Pharmaceutical Scie

• Sekine Michikazu

  Department Of Welfare Promotion And Epidemiology Graduate School Of Medicine And Pharmaceutical Scie

• KAGAMIMORI Sadanobu

  Department of Community Health and Preventive Medicine, Toyama Medical and Pharmaceutical University

• SEKINE MICHIKAZU

  Department of Surgery, School of Medicine, Keio University

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