Effect of Moderate Alcohol Intake on Nocturnal Sleep Respiratory Parameters in Healthy Middle-Aged Men

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概要

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• Purpose:It is known that a moderate to large volume of alcohol produces deterioration in obstructive sleep apnea (OSA), however, no consensus has been achieved with respect to the influence of a moderate volume of alcohol on mild to moderate OSA. In this study, we investigated the influence of alcohol on OSA-associated parameters in healthy middle-aged males drinking a moderate volume of alcohol (<1 g alcohol/kg bodyweight per day). Methods:Subjects were 23 healthy males (mean age of 46.0) with a habitual ingestion of moderate amounts of alcohol. Respiratory sleep parameters were measured through the fitting of an Apnomonitor III (Chest Inc.) and portable sleep monitoring device (Actiwatch:AMI Inc.) to subjects on three nights;an alcohol-free night, a night on which they drank alcohol with dinner, and a night on which they drank alcohol within 30 minutes before retiring to bed. The measurements were categorized into the early and late halves of assumed sleep for analysis. Results:The apnea-hypopnea index was significantly higher when drinking alcohol before retiring [mean (SD):7.8 (8.2) events/hour] than the values on the alcohol-free day [2.9 (4.5) events/hour] and when drinking alcohol with dinner [3.8 (5.3) events/hour]. Furthermore, drinking alcohol before retiring resulted in lower arterial blood oxygen saturation (SpO_2) during the early half of sleep [94.8 (1.4) %] when compared to the values on the alcohol-free day [95.7 (1.3) %] and drinking alcohol with dinner [95.4 (1.6) %]. In addition, the percentage of time with SpO_2 <92% (hypoxic event) during the early half of sleep [4.9 (9.3) %] was significantly higher than the values on the alcohol-free day [1.2 (1.8) %] and when drinking alcohol with dinner [1.4 (1.8) %]. Conclusion:These results suggest that moderate ingestion of alcohol within 30 minutes before retiring aggravates OSA-associated parameters in healthy males.

• 日本衛生学会の論文

著者

• KAGAMIMORI SADANOBU

  Department of Welfare Promotion and Epidemiology, Toyama Medical and Pharmaceutical University

• Nasermoaddeli Ali

  Department of Epidemiology and Public Health, Kanazawa Medical University

• Nasermoaddeli Ali

  Department Of Welfare Promotion And Epidemiology Graduate School Of Medical Sciences University Of T

• ナセルモアデリ アリ

  富山医科薬科大学保健医学教室

• Nasermoaddeli Ali

  Department Of Epidemiology And Public Health Kanazawa Medical University

• Kagamimori S

  Department Of Welfare Promotion And Epidemiology Faculty Of Medicine University Of Toyama

• Kagamimori Sadanobu

  聖マリアンナ医科大学 予防医学

• Kagamimori Sadanobu

  Department Of Community Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical University

• Suka Machi

  Department Of Preventive Medicine St Marianna University School Of Medicine

• SEKINE Michikazu

  Department of Welfare Promotion and Epidemiology, Toyama Medical and Pharmaceutical University

• Kagamimori Sadanobu

  Department Of Welfare Promotion And Epidemiology Graduate School Of Medicine And Pharmaceutical Scie

• IZUMI Ichiro

  Department of Welfare Promotion and Epidemiology, Faculty of Medicine, Toyama Medical and Pharmaceut

• Izumi Ichiro

  Department Of Welfare Promotion And Epidemiology Faculty Of Medicine Toyama Medical And Pharmaceutic

• Sekine Michikazu

  Department Of Welfare Promotion And Epidemiology Graduate School Of Medicine And Pharmaceutical Scie

• KAGAMIMORI Sadanobu

  Department of Community Health and Preventive Medicine, Toyama Medical and Pharmaceutical University

• SEKINE MICHIKAZU

  Department of Surgery, School of Medicine, Keio University

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