Increased T-cell Receptor Mutation Frequency in Radiation-Exposed Residents Living Near the Semipalatinsk Nuclear Test Site
スポンサーリンク
概要
- 論文の詳細を見る
From 1949 to 1989, 488 nuclear explosions were carried out in Semipalatinsk, and the cancer risk is increased in this region. Measuring somatic-cell mutation frequencies may be a useful tool for evaluating cancer risk within radiation-exposed populations. Here, we report the first evidence of increased T-cell receptor (TCR) mutations in peripheral blood from radiation-exposed residents of Semipalatinsk. The TCR mutation frequency in the highly exposed residents (Dolon and Sarzhal) was significantly higher than in the control group (Kokpekti). There was no statistically significant difference between the control group and the weakly exposed group (Kaynar and Semipalatinsk-city). The TCR mutation assay appeared to be a useful biological dosimeter even after a period of 40 years since radiation exposure. This may be the result of specific conditions, such as the presence of internal exposure.
- 日本放射線影響学会の論文
著者
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HOSHI MASAHARU
Research Institute for Radiation Biology and Medicine, Hiroshima University
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星 正治
広島大学原爆放射能医学研究所 国際放射線情報センター
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星 正治
岡山理科大学 理学部応用物理学科
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星 正治
広島大学・原爆放射線医科学研究所国際放射線情報センター
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峠岡 康幸
Research Institute For Radiation Biology And Medicine Hiroshima University
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TAOOKA Yasuyuki
Research Institute for Radiation Biology and Medicine, Hiroshima University
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TAKEICHI Nobuo
Takeichi Hiroshima Thyroid Medical Clinic
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NOSO Yoshihiro
Department of surgery, Hiroshima Saisei-kai Hospital
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KAWANO Noriyuki
Research Institute for Radiation Biology and Medicine, Hiroshima University
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APSALIKOV Kazbek
Kazakhstan Research Institute for Radiation Medicine and Ecology
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峠岡 康幸
マツダ病院
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星 正治
広島大学原爆放射線医科学研究所・線量測定・評価研究分野
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Apsalikov Kazbek
Kazakh Scientific Res. Inst. For Radiation Medicine And Ecology
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Apsalikov Kazbek
Kazakh Scientific Research Institute For Radiation Medicine And Ecology
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Apsaliko K.
Scientifical Research Institute For Radiation Medicine (srirm)
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Noso Yoshihiro
Saiseikai Hiroshima Hospital
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Apsalikov Kazbek.
Kazakh Research Institute For Radiation Medicine And Ecology
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Takeichi Nobuo
Takeichi Clinic
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Takeichi N
Hiroshima Univ. School Of Medicine Hiroshima Jpn
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Taooka Yasuyuki
The Department Of Respiratory Disease Hiroshima Red Cross Hospital And Atomic Bomb Survivors Hospita
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Hoshi Masaharu
Research Institute For Nuclear Medecine And Biology Hiroshima University
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Hoshi Masaharu
Hiroshima University
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Taooka Yasuyuki
Research Institute For Radiation Biology And Medicine Hiroshima University
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