Thyroid Abnormality Trend Over Time in Northeastern Regions of Kazakstan, adjacent to the Semipalatinsk Nuclear Test Site : A Case Review of Pathological Findings for 7271 Patients

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概要

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• From 1949 through 1989 nuclear weapons testing carried out by the former Soviet Union at the Semipalatinsk Nuclear Test Site (SNTS) resulted in local fallout affecting the residents of Semipalatinsk, Ust-Kamenogorsk and Pavlodar regions of Kazakstan. To investigate the possible relationship between radiation exposure and thyroid gland abnormalities, we conducted a case review of pathological findings of 7271 urban and rural patients who underwent surgery from 1966・6. Of the 7271 patients, 761 (10.5%) were men, and 6510 (89.5%) were women. The age of the patients varied from 15 to 90 years. Overall, a diagnosis of adenomatous goiter (most frequently multinodular) was found in 1683 patients (63.4%) of Semipalatinsk region, in 2032 patients (68.6%) of Ust-Kamenogorsk region and in 1142 patients (69.0%) of Pavlodar region. In the period 1982-96, as compared before, there was a noticeable increase in the number of cases of Hashimoto痴 thyroiditis and thyroid cancer. Among histological forms of thyroid cancer, papillary (48.1%) and follicular (33.1%) predominated in the Semipalatinsk region. In later periods (1987-96), an increased frequency of abnormal cases occurred among patients less than 40 years of age, with the highest proportion among patients below 20 in Semipalatinsk and Ust-Kamenogorsk regions of Kazakstan. Given the positive findings of a significant cancer-period interaction, and a significant trend for the proportion of cancer to increase over time, we recommend more detailed and etiologic studies of thyroid disease among populations exposed to radiation fallout from the SNTS in comparison to non-exposed population.

• 日本放射線影響学会の論文

著者

• TAKADA JUN

  Research Institute for Radiation Biology and Medicine, Hiroshima University

• HOSHI MASAHARU

  Research Institute for Radiation Biology and Medicine, Hiroshima University

• 高田 純

  Department Of Physics School Of Medicine Sapporo Medical University

• TAKEICHI Nobuo

  Takeichi Hiroshima Thyroid Medical Clinic

• Gusev Boris

  Scientifical Research Institute For Radiation Medicine (srirm)

• Gusev B.

  Kazakh Scientific Research Inst. Radiation Medicine And Ecology

• Gusev Boris

  Scientifical Res. Inst. For Radiation Medicine (srirm)

• Gusev Boris

  Kazakh Science Research Institute For Radiation Medicine And Ecology

• HAYAKAWA NORIHIKO

  Research Institute for Radiation Biology and Medicine, Hiroshima University

• ZHUMADILOV Zhaxybay

  Semipalatinsk State Medical Academy

• Kimura Akiro

  Hiroshima Univ. Hiroshima Jpn

• Kimura Akiro

  放射線医学総合研究所

• Kimura Akiro

  Research Institute For Nuclear Medicine And Biolosy. Hiroshima University.

• Takada J

  Okayama Univ. Okayama Jpn

• Takeichi Nobuo

  Takeichi Clinic

• Takeichi N

  Hiroshima Univ. School Of Medicine Hiroshima Jpn

• Zhumadilov Ozhaxybay

  広島大学原爆放射能医学研究所

• Hoshi Masaharu

  Research Institute For Nuclear Medecine And Biology Hiroshima University

• Hayakawa N

  Department Of Epidemiology Research Institute For Radiation Biology And Medicine Hiroshima Universit

• Takada Jun

  Research Institute For Nuclear Medicine And Biology Hiroshima University

• Hayakawa Norihiko

  Research Institute For Radiation Biology &medicine Hiroshima Univ.

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