Some Approaches to Treatment of Patients with Thyroid Nodular Diseases in the Semipalatinsk Region of Kazakhstan

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概要

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• It was determined by experts that in the region adjacent to the Semipalatinsk Nuclear Test Site thyroid nodular prevalence was significantly associated with radiation dose from nuclear weapons testing. The medical rehabilitation of patients is of special practical and scientific importance in this region. Some patients have contraindications for surgery and radioiodine or refuse them for various reasons. Percutaneous intranodular injection therapy by "Paoscle" (PIITP) was used for treatment of patients with benign thyroid nodular diseases. The study group included a total of 107 patients (mainly "pretoxic" and "compensated" nodules). Seventyfour patients received PIITP on an out-patient basis. Seventy-two of them were women and 2 men, mean age, 52.9±1.3 years; range 26 to 77 years. Thyroid ultrasound examination, fineneedle aspiration biopsy, thyroid function tests and cytopathology were performed in all patients to evaluate the effectiveness of treatment. The nodule volume reduction rate for patients with thyroid adenomas was 56% on average and 60.2% in the case of colloid nodules. The reduction rate of thyroid adenomas with necrotic and cystic degeneration was higher and reached 72%. The suggested method is indicated for cases of benign nodular thyroid diseases (cysts, adenomas, adenomas with necrotic and cystic degeneration, colloid nodules, polynodular goiter). We did not reveal any complications or thyroid test abnormalities after the treatment. A tendency to normalization of the blood serum thyroglobulin level and antibodies to thyroglobulin was documented. Analysis of the treatment results revealed that this approach is effective, inexpensive, safe, well tolerated and can be used on an outpatient basis.

• 広島大学の論文

著者

• 峠岡 康幸

  Research Institute For Radiation Biology And Medicine Hiroshima University

• TAKEICHI Nobuo

  Takeichi Hiroshima Thyroid Medical Clinic

• ZHUMADILOV Zhaxybay

  International Radiation Information Center, Research Institute for Radiation Biology and Medicine, H

• HOSHI Masaharu

  International Radiation Information Center, Research Institute for Radiation Biology and Medicine, H

• ABISHEVA Gulniaz

  Semipalatinsk State Medical Academy

• TAOOKA Yasuyuki

  International Radiation Information Center, Research Institute for Radiation Biology and Medicine, H

• BHATTARCHARJEE Deborshi

  Semipalatinsk State Medical Academy

• KAMIYA Kenji

  Department of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshim

• ZHUMADILOV Zhaxybay

  Semipalatinsk State Medical Academy

• Takeichi Nobuo

  Takeichi Clinic

• Takeichi N

  Hiroshima Univ. School Of Medicine Hiroshima Jpn

• Taooka Yasuyuki

  The Department Of Respiratory Disease Hiroshima Red Cross Hospital And Atomic Bomb Survivors Hospita

• Taooka Yasuyuki

  International Radiation Information Center Research Institute For Radiation Biology And Medicine Hir

• Zhumadilov Ozhaxybay

  広島大学原爆放射能医学研究所

• Kamiya Kenji

  Department Of Developmental Biology And Oncology Research Institute For Radiation Biology And Medici

• Kamiya Kenji

  Department Of Experimental Oncology Research Institute For Radiation Biology And Medicine Hiroshima

• Hoshi Masaharu

  International Radiation Information Center Hiroshima University

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