RBE-LET Relationships of High-LET Radiations in Drosophila Mutations
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概要
- 論文の詳細を見る
The relative biological effectiveness (RBE) of ^<252>Cf neutrons and synchrotron-generated high-energy charged particles for mutation induction was evaluated as a function of linear energy transfer (LET), using the loss of heterozygosity for wing-hair mutations and the reversion of the mutant white-ivory eye-color in Drosophila melanogaster. Loss of heterozygosity for wing-hair mutations results predominantly from mitotic crossing over induced in wing anlage cells of larvae, while the reverse mutation of eye-color is due to an intragenic structural change (2.96 kb-DNA excision) in the white locus on the X-chromosome. The measurements were performed in a combined mutation assay system so that induced mutant wing-hair clones as well as revertant eye-color clone can be detected simultaneously in the same individual. Larvae were irradiated at the age of 3 days post oviposition with ^<252>Cf neutrons, carbon beam or neon beam. For the neutron irradiation, the RBE values for wing-hair mutations were larger than that for eye-color mutation by about 7 fold. The RBE of carbon ions for producing the wing-hair mutations increased with increase in LET. The estimated RBE values were found to be in the range 2 to 6.5 for the wing-hair. For neon beam irradiation, the RBE values for wing-hair mutations peak near 150 keV/mm and decrease with further increase in LET. On the other hand, the RBE values for the induction of the eye-color mutation are nearly unity in ^<252>Cf neutrons and both ions throughout the LET range irradiated. We discuss the relationships between the initial DNA damage and LET in considering the mechanism of somatic mutation induction.
- 日本放射線影響学会の論文
著者
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高田 純
Department Of Physics School Of Medicine Sapporo Medical University
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HOSHI Masaharu
International Radiation Information Center, Research Institute for Radiation Biology and Medicine, H
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TAKATSUJI Toshihiro
Faculty of Environmental Studies, Nagasaki University
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YOSHIKAWA Isao
Faculty of Environmental Studies, Nagasaki University
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遠藤 暁
Mechanical System Engineering Graduate School Of Engineering Hiroshima University
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Endo Satoru
Department Of Biochemistry Cancer Institute Okayama University Medical School
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Takada J
Okayama Univ. Okayama Jpn
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Yoshikawa Isao
Faculty Of Environmental Studies Nagasaki University
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Yoshikawa Isao
Department Of Genetics Nagasaki University School Of Medicine
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Yoshikawa Isao
Institute Of Industrial Science University Of Tokyo
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NAGANO MASAAKI
Faculty of Environmental Studies, Nagasaki University
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TAKADA JUN
International Radiation Information Center, Research Institute for Radiation Biology and Medicine, H
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Nagano Masaaki
Faculty Of Environmental Studies Nagasaki University
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Endo Satoru
Div. Environ. Biol. Res. Inst. Rad. Biol. And Med. Hiroshima University
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Yoshikawa Isao
Dept. Genet. Nagasaki Univ. Sclt Med.
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Takatsuji Toshihiro
Faculty Of Environmental Studies Nagasaki University
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Takatsuji Toshihiro
Graduate School Of Environmental Science Nagasaki University
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Hoshi Masaharu
International Radiation Information Center Hiroshima University
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Takada Jun
International Radiation Information Center Research Institute For Radiation Biology And Medicine Hir
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