Small Kidney : A Clinical Study Estimation of Progression of Renal Failure

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Sixteen cases with an initial diagnosis of hypoplastic or small kidney detected by IVP, VCG, echogram, RI scan, CT scan or angiography were studied. We investigated to find out what common factors affect their growth, the rate of change of creatinine concentration, and to find out possible effects of medical therapy. Height and weight were graphed, which were well correlated with linear regression of the serum creatinine versus time. Analysis of these relation gave an estimation of progression of disease, the possible effects of therapy and to predict when dialysis will become necessary. The commonest reason for discovery were firstly due to episodes of urinary tract infection and secondary by routine school check ups for urinalysis (5/16). Of the 16 patients that were found to have a small kidney, 10 was finally diagnosed to have hypoplastic kidney, 5 were bilateral, 5 were unilateral. Of the patients that were found to have an atrophic kidney secondary to pyelonephritis, 3 of them were associated with bilateral VUR, one was associated with unilateral VUR. Impairment of renal function was observed in those who have bilateral renal anomaly with VUR, or who have unilateral UPJ obstruction and agenesis of another kidney. The important roles of the pediatrician in prevention of chronic renal failure among those children are early recognition of the urinary tract infections which damage the renal function in them. Screening of proteinuria, hematuria and hypertension in asymptomatic children with renal anomaly is also useful in early detection in them, and is essential for the prevention of the development of chronic renal failure.
北里大学の論文
1988-04-30

Small Kidney : A Clinical Study Estimation of Progression of Renal Failure

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