薬剤の安定性に関する研究(第18報) : ベンゾサイアダイアジン系化合物の安定性その9 : クロロサイアザイドのアルカリ水溶液中における逐次分解反応の中間体生成の最適条件について

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The present investigation was undertaken to obtain, not using trial-and-error method but a mathematical one, the optimum for the production of the intermediate in the degradation of chlorothiazide (I). I decomposes to 4-amino-6-chloro-m-benzenedisulfonamide (IV) via consecutive reversible reactions, leading to the formation of N-(2-amino-4-chloro-5-sulfa-moylphenylsulfonyl) formamide (II) in aqueous alkali : [numerical formula]. II has a maximum concentration [II]_<max> at [t]_<max>, and [II]_<max> was affected by the variation of pH. The [II]_<max> had the maximum value of 65% of[I]_0 at pH 7.6 by the calculation based on : k_1=1.2×10^<-2>min^<-1>, k_2=6.5×10^<-3>min^<-1>, and k_3=2.0×10^<-4>min^<-1>.
公益社団法人日本薬学会の論文
1967-12-25