Stabilization of Drugs. I. The Quantitative Prediction of the pH-Dependency of Amide and Anilide Hydrolyses by Neighboring Hydroxyl Groups
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概要
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Intramolecular hydrolyses of amides and anilides were examined over wide pH ranges at 90°. Shape of pH-rate plofiles indicates that the relative reactivity of ionized (k'_<RO>^-) and un-ionized (k'_<ROH>) alcohol functions toward amide linkage is governed by difference in pKa between attacking group alcohol and leaving group amine. As predicted from the theoretical consideration, their rate constants, k'_<RO>^- and k'_<ROH>, were found to have good linear free-energy correlation.
- 公益社団法人日本薬学会の論文
- 1973-04-25
著者
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山名 月中
Hospital Pharmacy School Of Medicine Kanazawa University
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辻 彰
Faculty of Pharmaceutical Sciences
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水上 勇三
金沢大学薬学部
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山名 月中
Faculty of Pharmaceutical Sciences, Kanazawa University
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水上 勇三
Faculty of Pharmaceutical Sciences, Kanazawa University
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