Stabilization of Drugs. II. Neighboring Amide Group Participation in Acidic Hydrolysis of Amide
スポンサーリンク
概要
- 論文の詳細を見る
Intramolecular catalyzed hydrolysis of amide bond by a second amide group was investigated in the acidic hydrolysis of 2-acylamidobenzamide as model compound. In the 2-arylamido series, the hydrolysis rate decreases as the substituent becomes more electron withdrawing. A Hammett reaction constant was found to be -1.05 and is consistent with the intramolecular catalyzed mechanism. The connection between the present results and penicillin stability in an acidic medium was discussed.
- 公益社団法人日本薬学会の論文
- 1974-03-25
著者
-
山名 月中
Hospital Pharmacy School Of Medicine Kanazawa University
-
辻 彰
Faculty of Pharmaceutical Sciences
-
水上 勇三
金沢大学薬学部
-
山名 月中
Faculty of Pharmaceutical Sciences, Kanazawa University
-
水上 勇三
Faculty of Pharmaceutical Sciences, Kanazawa University
関連論文
- Kinetic Analysis of the Peritoneal Transport of Quinolonecarboxylic Acids in Rats
- Comparative Pharmacokinetics of Cefazolin in Awake and Urethane-Anesthetized Rats
- Physicochemical Properties of Amphoteric β-Lactam Antibiotics. III. Stability, Solubility, and Dissolution Behavior of Cefatrizine and Cefadroxil as a Function of pH
- IC-17 Phenytoinによりてんかん発作消失後不随意運動を生じた脳炎の1例
- A Physiologically Based Pharmacokinetic Model for Biperiden in Animals and Its Extrapolation to Humans(Pharmaceutical)
- Simultaneous Microdetermination of Biperiden, Haloperidol, and Trihexyphenidyl in Plasma and Its Application to Pharmacokinetic Analysis after Concomitant Intravenous Administration of the Drugs to Rabbits
- IC-2 Sodium Valproate血中濃度の日内変動、薬動力学的考察
- Studies on Transfer Ribonucleic Acids and Related Compounds. VII. Synthesis and Properties of Cyclic Oligoadenylic Acids
- Physicochemical Properties of Amphoteric β-Lactam Antibiotics. IV. First- and Second-Order Degradations of Cefaclor and Cefatrizine in Aqueous Solution and Kinetic Interpretation of the Intestinal Absorption and Degradation of the Concentrated Antibiotics
- IIB-5 てんかん発作重積のPhenytoin治療
- IIB-6 てんかん発作重積のPhenytoin治療 : 薬物力動学応用の試みから
- 薬剤の安定性に関する研究(第26報)ベンゾサイアダイアジン系化合物の安定性 その13 o-アミノベンゼンスルホンアミド誘導体の閉環反応
- Kinetic Approach to the Development in β-Lactam Antibiotics. II. Prodrug. (1). Simultaneous Determination of Hetacillin and Ampicillin, and Its Application to the Stability of Hetacillin in Aqueous Solution
- 有機溶媒緩衝液混合系におけ特殊酸・塩基触媒反応の速度定数とpHとの関係
- Kinetic Approach to the Development in β-Lactam Antibiotics. I. Comparative Stability of Semisynthetic Penicillins and 6-Aminopenicillanic Acid in Aqueous Solution
- Stabilization of Drugs. II. Neighboring Amide Group Participation in Acidic Hydrolysis of Amide
- Stabilization of Drugs. I. The Quantitative Prediction of the pH-Dependency of Amide and Anilide Hydrolyses by Neighboring Hydroxyl Groups
- Studies on the Stability of Amides. V. A Comparison of Intramolecular Catalysis by Phenolic and Alcoholic Hydroxyl Groups in Amide Hydrolysis
- Studies on the Stability of Amides. III. Hydrolysis of Amides in Aqueous Perchloric Acid Solution
- Studies on the Stability of Amides. IV. Intramolecular Hydroxyl Group Participation in the Acidic Hydrolysis of Aliphatic Amides
- Studies on the Stability of Amides. II. Intramolecular Hydrogen Bond in 4-Hydroxyvaleramide
- Studies on the Stability of Amides. I. Hydrolysis Mechanism of N-Substituted Aliphatic Amides
- 薬剤の安定性に関する研究(第22報) : ベンゾサイアダイアジン系化合物の安定性その12クロロサイアザイドの分解機構について
- 酸性水溶液中でのグルクロン酸エチルエステルの加水分解反応特にリン酸緩衝液中での反応について
- 薬剤の安定性に関する研究(第20報) : ベンゾサイアダイアジン系化合物の安定性 その11 : ハイドロクロロサイアザイドの酸およびアルカリ性水溶液中における分解について
- 薬剤の安定性に関する研究(第19報) : ベンゾサイアダイアジン系化合物の安定性 その10 : 混合溶媒中におけるクロロサイアザイドの加水分解反応について
- 酸性水溶液中でのグルクロン酸アミドの加水分解反応特にリン酸緩衝液中での反応について
- グルクロノラクトンのリン酸緩衝液中での加水分解反応について
- Studies on the Stability of Drugs. XVII. Stability of Benzothiadiazines. (8). Kinetics of Acid-Base Catalysed Hydrolysis of Chlorothiazide
- 薬剤の安定性に関する研究(第18報) : ベンゾサイアダイアジン系化合物の安定性その9 : クロロサイアザイドのアルカリ水溶液中における逐次分解反応の中間体生成の最適条件について
- 薬剤の安定性に関する研究(第15報) : ベンゾサイアダイアジン系化合物の安定性その7 : 酸性溶液中におけるクロロサイアザイドの分解についてその2
- On the Acid Hydrolysis Mechanism of Ethyl D-Glucuronate.
- Specific Binding of β-Endorphin to the Isolated Renal Basolateral Membranes in Vitro