β-ラクタム系抗生物質の分析化学的研究(第1報)ヨウ素滴定法による半合成ペニシリン類の定量

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An iodometric method was developed for the quantitative determination of new semisynthetic penicillins, sodium (2S, 5R, 6R)-6-[(R)-2-(4-hydroxy-1,5-naphthyridine-3-carboxamido-2-phenyl acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylate (PC-904,apalcillin sodium) and sodium (2S, 5R, 6R)-6-[(R)-2-(4-hydroxy-1,5-naphthyridine-3-carboxamido)-2-(4-hydroxyphenyl) acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylate (PC-462). These antibiotics were hydrolyzed to form corresponding penicilloic acids which consumed iodine. Accuracy and precision of this method depended upon the pH at which their penicilloic acids reacted with iodine, and pH 1.5±0.2 was found to be optimum. One mole of PC-904,PC-462,ampicillin or amoxycillin consumed 9.7 gramatom of iodine. The analytical results obtained by the iodometric method were in good agreement with those obtained by bioassay, including some samples partially decomposed.
公益社団法人日本薬学会の論文
1979-07-25