利水作用を有する生薬のウマ腎臓(Na^++K^+)-Adenosine Triphosphataseに対する影響

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In the folk-medicine, several kinds of crude drugs are used as diuretics. Twenty three kinds of diuretic drugs were chosen, and examined for their effects on the horse kidney (Na^++K^+)-adenosine triphosphatase (ATPase), which is an intrinsic enzyme of the plasma membrane and responsible for the active transport of Na^+ and K^+ across the membrane. Twenty one out of twenty three kinds of ethanol extracts of diuretic drugs inhibited the kidney (Na^++K^+)-ATPase activity. The intensity of the inhibition of these drugs was compared by estimating the amounts of their ethanol extracts which inhibited the (Na^++K^+)-ATPase activity by 50% (I_<50>, μg/ml). Among these drugs, Atractylodis Lanceae Rhizoma (蒼朮, I_<50>=12.8) Atractylodis Rhizoma (白朮, I_<50>=15.2), Plantaginis Semen (車前子, I_<50>=16.0), Plantaginis Herba (車前草, I_<50>=16.0) and Alismatis Rhizoma (沢瀉, I_<50>=22.0), have strong inhibitory effects on the kidney (Na^++K^+)-ATPase activity. The ethanol extracts of the rhizomes of Atractylodes lancea DE CANDOLLE (古立蒼朮) and Atractylodis japonica KITAMURA (和白朮) were examined with varying concentrations of ATP and ouabain. The mode of inhibition of these two extracts on the (Na^++K^+)-ATPase activity appeared to be uncompetitive with respect to ATP as judged from Line-weaver-Burk plot. The ethanol extract of Atractylodes japonica KITAMURA decreased the I_<50> for ouabain from 1.6×10^<-7> to 7.0×10^<-9>M, while that of Atractylodes lancea DE CANDOLLE did not change the I_<50> for ouabain.
社団法人日本薬学会の論文
1991-02-25

利水作用を有する生薬のウマ腎臓(Na^++K^+)-Adenosine Triphosphataseに対する影響

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