THERAPY FOR UROLITHIASIS WITH HYDROXAMIC ACIDS. IV. PREVENTION OF INFECTED URINARY STONE FORMATION WITH N-(PIVALOYL) GLYCINOHYDROXAMIC ACID
スポンサーリンク
概要
- 論文の詳細を見る
With the aim of finding a prospective therapeutic compound with a promising potential for the treatment of urolithiasis, we evaluated the effectiveness of a new potent inhibitor of urease, N-(pivaloyl) glycinohydroxamic acid. The present study revealed that N-(pivaloyl) glycinohydroxamic acid effectively inhibited the alkalinization of urine and the stone formation in vitro and in vivo, due to its strong inhibitory potency against the ureolytic activity of intact Proteus mirabilis. The possibility of the clinical application of this compound in the prevention of struvite stone formation caused by infection of urea-splitting bacteria awaits evaluation of the safety of this compound.
- 公益社団法人日本薬学会の論文
著者
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YOSHIDA Osamu
Department of urology, Faculty of Medicine, Kyoto University
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Takeuchi Hideo
Department of Information Electronics, School of Engineering, Nagoya University
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KANAZAWA TAMOTSU
Research Laboratories, Eisai Co., Ltd.
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Takeuchi Hideo
Department Of Applied Physics Faculty Of Engineering Osaka City University
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Yoshida Osamu
Department Of Cardiology Komatsushima Red Cross Hospital
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Kanazawa Tamotsu
Research Laboratories Eisai Co. Ltd.
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Takeuchi Hideo
Department Of Urology Faculty Of Medicine Shiga Medical University
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Yoshida Osamu
Department Of Agricultural Chemistry Faculty Of Horticulture Chiba University
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