Cataracts in Rats Given a Bladder Carcinogen, N-Butyl-N-(4-Hydroxybutyl)-Nitrosamine
スポンサーリンク
概要
- 論文の詳細を見る
Cataracts were incidentally found at week 30 in six out of 65 female Wistar rats given a urinary bladder carcinogen, N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in a 0.05% solution in drinking water for 8 weeks and then treated with mitomycin C, a retinoid or a combination of both. No cataracts were found in 12 control rats given no carcinogen. Although the difference in the incidence was not significant statistically, the present finding suggests the possibility that administration of BBN induces or facilitates the development of cataracts.
- 東海大学の論文
著者
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YOSHIDA Osamu
Department of urology, Faculty of Medicine, Kyoto University
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Fujita Jun
Department of Cardiology, Keio University School
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Fujita Hiromi
Nakano Eye Clinic Nakagyo-ku Kyoto
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MIKUNI Ikuo
Department of Ophthalmology, School of Medicine, Tokai University
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Mikuni Ikuo
Department Of Ophthalmology School Of Medicine Tokai University
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Yoshida Osamu
Department Of Cardiology Komatsushima Red Cross Hospital
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Fujita Jun
Department Of Urology Faculty Of Medicine Kyoto University
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Yoshida Osamu
Department Of Agricultural Chemistry Faculty Of Horticulture Chiba University
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