Structure-Specificity Relationship of Cardiac Glycosides as a Substrate for Glucohydrolase II
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概要
- 論文の詳細を見る
Cardenolide glucohydrolase II (CGH II) is a cardenolide-specific glucohydrolase obtained from Digitalis lanata leaves. We investigated the structure-specificity relationship of several cardenolide disaccharides as a substrate for CGH II. Conformation analysis of the substrates was performed using molecular mechanics calculations. The sugar chain conformation of two inert glycosides was significantly different from that of the other glycosides. The other two glycosides, which were weak substrates of CGH II, were suggested to have an intramolecular hydrogen bond between the sugar groups. It was deduced that this hydrogen bond restricts the conformational change of the sugar chain and prevents the glycosides from enzymatic recognition.
- 公益社団法人日本薬学会の論文
- 2000-03-01
著者
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Watanabe Naoharu
Department Of Agricultural Chemistry The University Of Tokyo
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Watanabe Naoharu
Department Of Applied Biological Chemistry Shizuoka University
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Terada Y
Faculty Of Pharmacy Meijo University
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Terada Yukimasa
Faculty Of Pharmacy Meijo University
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MISOI Rumi
Faculty of Pharmacy, Meijo University
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HORNBERGER Martin
Lehrstuhl fur Pharmazeutische Biologie, Friedrich-Alexander-Universitat
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KREIS Wolfgang
Lehrstuhl fur Pharmazeutische Biologie, Friedrich-Alexander-Universitat
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Misoi Rumi
Faculty Of Pharmacy Meijo University
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Hornberger Martin
Lehrstuhl Fur Pharmazeutische Biologie Friedrich-alexander-universitat
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Kreis Wolfgang
Lehrstuhl Fur Pharmazeutische Biologie Friedrich-alexander-universitat
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