Studies on Analgesic Oligopeptides. VII. Solid Phase Synthesis and Biological Properties of Tyr-D-Arg-Phe-βAla-NH_2 and Its Fluorinated Aromatic Amino Acid Derivatives
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概要
- 論文の詳細を見る
Tyr-D-Arg-Phe-βAla-NH_2 (I) and its six fluorinated analogs were synthesized. Their opioid receptor binding properties were examined in vitro and their analgesic activity in vivo using the mouse writhing test. It was found that I was one of the most selective and potent μ-receptor agonists reported to date. [Tyr(2F)^1](VI) and [Tyr(3F)^1](V) derivatives of I showed similar biological properties to those of I. Since these peptides resist enzymatic degradation, it is expected that they are excellent reagents for the studies of function of μ-receptor-mediated biological properties in vivo and in vitro.
- 社団法人日本薬学会の論文
- 1991-09-25
著者
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鈴木 謙次
東北薬科大学
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安保 明博
Tohoku College of Pharmacy
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佐々木 有亮
Tohoku College of Pharmacy
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鈴木 謙次
Tohoku College of Pharmacy
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