Solid Phase Synthesis and Opioid Receptor Binding Activities of[D-Ala^2,D-Leu^5]Enkephalin Analogs Containing a Fluorinated Aromatic Amino Acid

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概要

• 論文の詳細を見る

• Five [D-Ala^2,D-Leu^<55>]enkephalin (DADLE) analogs containing fluorinated Tyr^1 or Phe^4 residue, that is, [Phe(2F)^4] (I), [Phe(3F)^4] (II), [Phe(4F)^4] (III), [Tyr(3F)^1] (IV) and [Try(2F)^1] (V), were synthesized by the solid phase method and their opioid receptor affinities were examined. Affinity profiles of five derivatives for the μ- and δ-receptor were similar to those of DADLE, and the affinity for κ-receptor was zero or negligible.

• 社団法人日本薬学会の論文
• 1990-11-25

著者

• 鈴木 謙次

  東北薬科大学

• 佐々木 有亮

  Tohoku College of Pharmacy

• 鈴木 謙次

  Tohoku College of Pharmacy

• 河野 弘之

  Tohoku College of Pharmacy

• 大久保 恭仁

  Tohoku College of Pharmacy

• 大久保 恭仁

  東北薬大

• 大久保 恭仁

  東北薬科大学 放射薬品

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