An Improved Attachment of N-Protected Amino Acid and Peptide to Chloromethylated Polystyrene-divinylbenzene Resin
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概要
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N-Protected amino acyl-or peptidyl-resin was prepared in good yield without racemization, when about a half equivalent amount of 1,5-diaza-bicyclo [4,3,0] nonene-5 (DBN) or 1,8-diaza-bicyclo [5,4,0] undecene-7 (DBU) salt of N-protected amino acid or peptide was allowed to react with chloromethylated polystyrene-2%-divinylbenzene resin (chlorine content 0.66 millimole per gram) at 50°for 28 hours. The unchanged chloromethyl group was acetylated quantitatively by the reaction with large excess of DBN salt of acetic acid.
- 公益社団法人日本薬学会の論文
- 1977-05-25
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