The γ-Phenacyl and γ-p-Nitrobenzyl Esters to Minimize Side Reactions during Treatment of Glutamyl Peptides with Hydrogen Fluoride-Anisole Mixture
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概要
- 論文の詳細を見る
For the synthesis of peptide containing glutamic acid residue (s) by solid phase peptide synthesis, γ-phenacyl or γ-nitrobenzyl ester group, which is stable to anhydrous hydrogen fluoride (HF), was used as γ-carboxyl protecting group of glutamic acid to minimize the side reactions. The protected peptide resins were treated with HF-anisole mixture followed by deprotection of the γ-carboxyl protecting group under mild conditions. This strategy gave a satisfactory result without detectable side reactions in the preparations of two model dipeptides, H-Ala-Glu-OH and H-Asn-Glu-OH, by solid phase peptide synthesis.
- 社団法人日本薬学会の論文
- 1977-10-25
著者
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鈴木 謙次
東北薬科大学
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佐々木 有亮
Tohoku College of Pharmacy
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鈴木 謙次
Tohoku College of Pharmacy
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遠藤 信義
Tohoku College of Pharmacy
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