Selective Cleavage of tert-Butyloxycarbonyl Protecting Group with Dilute Organic Sulfonic Acid without Decomposition of Tryptophan Residue

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概要

• 論文の詳細を見る

• The reagent of 2 M anhydrous p-toluenesulfonic acid in dioxane containing 2% anisole cleaves selectively tert-butyloxycarbonyl group in Boc-Trp-OH without any detectable decomposition of tryptophan residue. Another reagents such as dilute p-toluenesulfonic acid, methanesulfonic acid or ethanesulfonic acid in acetic acid and methanesulfonic acid or ethanesulfonic acid in dioxane, which are containing 2% anisole and 2% 1,2-ethanedithiol or triphenylphosphine as reducing reagent, have also similar properties to those of p-toluenesulfonic acid in dioxane containing 2% anisole. The utility of the reagents was proved as applied to the syntheses of three kinds of tryptophan containing peptide derivatives by the classical solution method.

• 社団法人日本薬学会の論文
• 1978-07-25

著者

• 鈴木 謙次

  東北薬科大学

• 佐々木 有亮

  Tohoku College of Pharmacy

• 鈴木 謙次

  Tohoku College of Pharmacy

• 遠藤 信義

  Tohoku College of Pharmacy

• 仁田 一雄

  Tohoku College of Pharmacy

• 仁田 一雄

  東北薬科大学

• 仁田 一雄

  東北薬科大学分子生体膜研究所分子認識学部門

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