Suppression of Diketopiperazine Formation in Solid Phase Peptide Synthesis
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概要
- 論文の詳細を見る
When N-methylmorpholine salt of Boc-Ile was coupled with HCl・Pro-Pro-resin suspended in methylenechloride by dicyclohexylcarbodiimide, diketopiperazine formation of the dipeptide-resin was suppressed almost completely and the isoleucine residue in the synthesized Boc-Ile-Pro-Pro-resin was not racemized. Generalization of this coupling procedure in a schedule for solid phase peptide synthesis is suggested.
- 公益社団法人日本薬学会の論文
- 1975-01-25
著者
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鈴木 謙次
Tohoku College of Pharmacy
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遠藤 信義
Tohoku College of Pharmacy
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仁田 一雄
Tohoku College of Pharmacy
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仁田 一雄
東北薬科大学
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仁田 一雄
東北薬科大学分子生体膜研究所分子認識学部門
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