Stereoselective Preparation of (1S, 2R)- and (1S, 2S)-2-Hydroxy-7,7-dimethylbicyclo[2.2.1]heptane-1-carboxylic Acids
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概要
- 論文の詳細を見る
Starting with (1S)-ketopinic acid (7,7-dimethyl-2-oxo-bicyclo[2.2.1]heptane-1-carboxylic acid), a facile high-yield synthesis of diastereomerically pure (1S, 2R)- and (1S, 2S)-2-hydroxy-7,7-dimethylbicyclo[2.2.1]heptane-1-carboxylic acids, potentially useful as chiral auxiliaries, has been achieved : the key step for the latter (2-endo isomer) involves the base-catalyzed epimerization of the (1S, 2R)-2-hydoxy isomer (2-exo-isomer), exclusively formed by the L-Selectride^<[○!R]> reduction of alkyl ketopinate, via the retro-aldol reaction.
- 公益社団法人日本薬学会の論文
- 1990-06-25
著者
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国枝 武久
Faculty of Pharmaceutical Sciences, University of Tokyo
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木村 是一
Faculty Of Pharmaceutical Sciences Kumamoto University
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国枝 武久
Faculty Of Pharmaceutical Sciences Kumamoto University
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石塚 忠男
Faculty of Pharmaceutical Sciences, Kumamoto University
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國枝 武久
Kumamoto Univ. Kumamoto Jpn
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石渕 正剛
Faculty of Pharmaceutical Sciences, Kumamoto University
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石塚 忠男
Fac. Of Medical And Pharmaceutical Sciences Kumamoto Univ.
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石渕 正剛
Faculty Of Pharmaceutical Sciences Kumamoto University
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