Facile Conversion of 4-Halogeno-1,3-dioxolan-2-ones to 2-Oxazolidones
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概要
- 論文の詳細を見る
Telomers of vinylenecarbonate with tetrachloromethane, which possess the 4-chloro-1,3-dioxolan-2-one structure as a terminal ring, underwent smooth and selective conversion with primary aliphatic amines into 5-substituted 4-hydroxy-2-oxazolidones whose chemical reactions with the aid of acids, dehydration and phenylation, led to the corresponding 4-oxazolin-2-ones and 4-phenyl-2-oxazolidones, respectively. Treatment of 5-trichloromethyl-2-oxazolidinone with zinc-methanol resulted in the exclusive formation of 5-dichloromethyl-2-oxazolidone, in contrast to the corresponding 1,3-dioxolan-2-one system which suffered complete reductive ring-opening even under milder conditions.
- 社団法人日本薬学会の論文
- 1977-06-25
著者
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滝沢 武夫
Faculty of Pharmaceutical Sciences, University of Tokyo
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国枝 武久
Faculty of Pharmaceutical Sciences, University of Tokyo
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松浦 勉
Faculty Of Pharmaceutical Sciences University Of Tokyo
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滝沢 武夫
Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address) Department Of Chemistry Uni
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国枝 武久
Faculty Of Pharmaceutical Sciences Kumamoto University
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