Oxidative Cleavage of Indoles using Copper-Pyridine Complex
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概要
- 論文の詳細を見る
Cu_2Cl_2-pyridine-O_2 system oxidize 2-and 3-substituted indole derivatives to form C_2-C_3 double bond cleaved products. By this reaction, 2-substituted indole (6a), 3-substituted indoles (1a-5a) and 2,3-disubstituted indole (7a) give N-acetylanthranic acid (6b), 2-acylformanilides (1b-5b) and quinolone derivative (7b), respectively. The reaction could represent a mimic of tryptophan 2,3-dioxygenase reaction, in which tryptophan undergoes oxidative cleavage to give N-formylkynurenin.
- 公益社団法人日本薬学会の論文
- 1979-02-25
著者
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滝沢 武夫
Faculty of Pharmaceutical Sciences, University of Tokyo
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沢井 宏明
Faculty Of Pharmaceutical Sciences University Of Tokyo
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滝沢 武夫
Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address) Department Of Chemistry Uni
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行正 秀文
Chemistry Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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行正 秀文
Faculty of Pharmaceutical Sciences, University of Tokyo Department of Chemistry, University of Tsuku
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