Syntheses of 1β-Methylcarbapenems Bearing 5-Methyl-4-hydroxypyrrolidinone
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概要
- 論文の詳細を見る
A new series of 1β-methylcarbapenems 1a-d bearing 5-methyl-4-mercaptopyrrolidinone rings has been prepared and evaluated for in vitro antibacterial activity and pharmacokinetic parameters. Most compounds showed excellent antibacterial activity and high stability to dehydropeptidase-1. We have synthesized optically active 5-methyl-4-hydroxypyrrolidinones from enantiomerically pure aziridine esters.
- 社団法人日本薬学会の論文
- 2002-03-01
著者
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KIM Bong
Korea Astronomy Observatory
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Lee Won
Department of Internal Medicine, institute of Medical Research, Sungkyunkwan University School of Me
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Kim Jae
Korea Aerospace Research Institute
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Lee Won
Department Of Chemistry Sogan University
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PYUN Do
Korea Research Institute of Chemical Technology;Department of Chemistry, Sogang University
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JUNG Hee
Korea Research Institute of Chemical Technology
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LEE Jin
Dong Wha Pharm. Ind. Co., Ltd.
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LEE Cheol
Korea Research Institute of Chemical Technology
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Jung H
Korea Research Institute Of Chemical Technology
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Lee Won
Department Of Agricultural And Biological Engineering University Of Florida
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Kim J
Korea Research Institute Of Chemical Technology
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Pyun D
Korea Research Institute Of Chemical Technology;department Of Chemistry Sogang University
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Kim B
Korea Research Institute Of Chemical Technology
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Lee C
Korea Research Institute Of Chemical Technology
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Lee Jin
Dong Wha Pharm. Ind. Co. Ltd.
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Lee Cheol
Korea Atomic Energy Research Institute
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