劇症肝不全に対する直並列回路PE+CHDF(<特集>劇症肝炎の治療をめぐって)

概要

論文の詳細を見る
Plasma exchange (PE) is a well-established blood purification therapy for treating fulminant hepatic failure. However, we previously reported that cytokines are not removed by PE alone, and combining PE and continuous hemodiafiltration (CHDF) is an effective modality for suppressing the elevation of blood citrate levels and for removing inflammatory cytokines. We devised a series-parallel method to raise the removal efficiency. In the series-parallel method, total bilirubin was significantly removed after treatment in comparison with the reverse-parallel method. Interleukin-18, which plays an important role in the pathophysiology of hepatic failure, was also significantly removed by the series-parallel method. The series-parallel method, which combines both advantages of the parallel and series methods, is a valuable therapy for the treatment of fulminant hepatic failure.
日本アフェレシス学会の論文
2003-10-31