Ontogeny of Estrogen Receptor (ER) ★ and ★ in the Female Reproductive Tissues of Mice Neonatally Exposed to Diethyistilbestrol
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概要
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Ontogenical expression of estrogen receptor (ER) isoforms, ER★ and ER★, was examined in order to study the roles of the isoforms in the morphogenesis of neonatal diethylstilbestrol (DES) treatment in the female reproductive tissues using an immunohistochemical method. The intensity of ER★ immunostaining gradually increased with aging in the epithelial cells of oviducts, uteri, cervices and vaginae in the vehicle-treated control animals. Neonatal DES-treatment up-regulated the expression of ER★ in the epithelial cells in these tissues and down-regulated it in the stromal cells at least until 10 days of age including the period of DES-treatment. On day 21, both control and DES-mice showed almost similar ER★ distribution in these tissues. There were no differences in the ER★ distribution in the ovaries of two experimental groups. ER★ was localized in the theca cells and some stromal cells located interfollicularly. Neonatal DES expo sure did not influence the distribution pattern of ER★ protein during the period of treatment and postnatal development. The nuclear ER★-immunoreaction was seen in the granulosa cells of ovaries but not in the cells of reproductive tracts. These results demonstrated that ER★ is the critical ER isoform for the estrogen-dependent responses in the normal female genital tract, and that the presence of ER★ in the epithelial cells during the period of DES exposure should play important roles in the the induction of abnormal characteristics in the genital tract of DES-mice.
- 日本組織細胞化学会の論文
著者
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Yamashita Shinsuke
Department Of Chemistry Naruto University Of Teacher Education
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Yamashina Shohei
Dept. Pharmaceutical Science Tohoku University
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Yamashita Shuji
Keio Junior Collge of Nursing
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Yamashita S
Keio Univ.
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Yamashita Shuji
Keio Junior College Of Nursing
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Yamashita Shuji
Keio Junior College Nursing
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