リボフラビン結晶の工業的製造に関する研究 : (VIII)3価チタン塩による還元法

概要

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Abilities of titanous, stanous and ferrous salts as reducing agents in the precipitation process of riboflavin were investigated. The results showed that titanous salt was most effective, stannous salt less effective and ferrous salt non-effective. The titanous solutions which were prepared by electrolytic reduction of pure titanic chloride solution in hydrochloric acid and ilmenite solution in sulfuric acid were almost equally useful. Reductive precipitation occurred most successfully at between 2 and 3 of final pH. In case of crude extract containing about 500 μg riboflavin per ml. for example, 2 equivalents of titanous salt for riboflavin were added to it and the resulting precipitate was filtered after standing for ten minutes and 85% of original riboflavin was recovered as a reduced form with a purity of 63%. Therefore, it is expected that this procedure predominate the hydrosulfite method employed up to this time.
日本ビタミン学会の論文