ビタミンB_1の拮抗物質にかんする研究 : (XVIII) アミノ酸共存におけるビタミンB_1アルカリ溶液からDesthiothiamine生成の反応条件

概要

論文の詳細を見る
It was observed that formation of desthiothiamine through the desulfurization of thiamine was remarkably increased in the presence of glycine or other twelve amino acid, i.e., α-alanine, valine, β-alanine, γ-aminobutyric acid, ε-aminocaproic acid, aspartic acid, glutamic acid, lysine, ornithine, arginine, serine and taurine with equimolar NaOH. Desthiothiamine was obtained in 78% yield when thiamine-HCl (1.55×10^<-2> mole) with equimolar glycine in a trimolar NaOH aqueous solution was incubated at 20℃ for three days. In the presence of other amino acid, desthiothiamine was obtained in 20 to 67% yield after the incubation for six days at 20℃. It was shown to be optimal to yield desthiothiamine that NaOH in 3.0 molar equivalents to thiamine-HCl with glycine or α-alanine, in 2.67 molar equivalents with β-alanine, and in 4.0 to 4.33 molar equivalents with aspartic acid were incubated for three or six days. Decrease in yield of desthiothiamine was observed when the above desulfurization of thiamine with amino acid was carried out at higher temperature above 60℃ for three or six hours.
日本ビタミン学会の論文
1968-04-25