グルタミン酸醗酵の連続化に関する基礎的研究 : (第4報) 直列4槽連続醗酵および増殖槽の挙動についての考察(生物化学工学特集号-II 滅菌および培養工学)

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In the previous studies of continuous three-stage fermentation, it was observed that the fermentation rate of the first fermentor (main growth fermentor) increased during the fermentation and became larger than that of batch fermentation with the same population size (see Fig. 1). In this study, this behavior of the growth fermentor was utilized to reduce the cycle time of continuous fermentation. The four-stage system was employed. The two stages were used as the growth fermentor and the latter two were used as the conversion fermentor. The results of continuous fermentation are presented in Fig. 4 and 5 and the comparisons of the fermentation rate between batch and continuous fermentation are presented in Table 2 and 3. From these results it was recognized that the cycle time of continuous fermentation can be reduced to that of batch fermentation.The behavior of the first fermentor was determined by the decrease of cells having Biotin absorption activity and the increase of aged cells produced in a continuous rotating vessel. This consideration was derived from the following facts.1) As is generally known, the growth and L-glutamate production of this microbedepend on the concentration of Biotin in a given medium. Biotin is almost completely absorbed by the cell in the earlier growth phase, and when the amount of Biotin in the cell is reduced during the growth the L- glutamate producing activity is induced.2) As seen in Fig. 2,the Biotin absorption rate of cells in batch fermentation decreased with the age of the culture, but it may heve resulted from the decrease of cells having Biotin absorption activity because the residual Biotin increased with the age of the culture.3) As seen in Fig. 3,the cells at the beginning of continuous fermentation have a high enough activity of Biotin absorption to maintain their cell concentration.From the above facts it was also considered that Biotin supplement in continuous fermentation may be useful to controll the changing of the cells from the growiny stage to the fermentative stage.
社団法人日本生物工学会の論文
1965-08-25

グルタミン酸醗酵の連続化に関する基礎的研究 : (第4報) 直列4槽連続醗酵および増殖槽の挙動についての考察(生物化学工学特集号-II 滅菌および培養工学)

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