ウナギに寄生する病原水生菌に対する抗黴性物質の検索

概要

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1) The antifungal effects of 117 compounds were examined against the fungus "Saprolegnia parasitica Coker" which is an eel parasitec. Among them, malachite green and 2-mercaptobenzothiazol were found to possess the highest effects, and their minimal growdth inhibitory concentration was 0.2 ppm. Minimal growth inhibitory concentrations of methyl violet, crystal violet, Hoffmann's violet, brilliant green, 2,3-bis(allyl-thiocarbamoylthio)-1-propanol, aniline blue, methyl green and tetracholrophenol were 0.5,1.0,1.0,1.0,1.0,2.0,2.0,and 5.0 ppm respectively, and those of the others were above 10 ppm.2) As the result of poison tests of these compounds on mice and loaches, the ratios of minimal lethal concentration to the minimal growth inhibitory concentration, the higher value of which may be regarded as an index of a promissing antifungal compound, of malachite green and Hoffmann's violet were found to be 10 in either case.
社団法人日本生物工学会の論文
1963-10-15