新展開に入った細胞の磁場配向技術

概要

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Magnetic orientations of biological macromolecules and floating cells in a liquid phase have been reported in previous studies. The summation of the diamagnetic anisotropies in each of the parts (peptide-bond, lipidmembrane, etc.) is responsible for the behavior of these "weak" diamagnetic materials under magnetic fields of several teslas. The present report reviews new topics related to adherent cell orientation under dc magnetic fields and associated phenomena. The adherent cells in blood vessels, smooth muscle cells, and endothelial cells, became oriented under magnetic fields in the order of 10 tesla. Increasing the magnetic flux density and adding proteins (collagen and fibrin) enhanced the orientation of cells. The proteins in which cells adhered, fibrin and collagen, generated magnetic-field-parallel and -perpendicular orientations, respectively. One possible application of the diamagnetic force acting on cells is the formation of artificial blood vessels.
2001-07-01