The Cytotoxicity of Microglass Fibers on Alveolar Macrophages of Fischer 344 Rats Evaluated by Cell Magnetometry, Cytochemisry and Morphology
スポンサーリンク
概要
- 論文の詳細を見る
Objectives : The toxicity of microglass fibers (MG), one of the man-made mineral fibers, has not been sufficiently evaluated. The aim of the current study was to evaluate the cytotoxicity of MG in vitro. Methods : Alveolar macrophages were obtained from the bronchoalveolar lavage of male F344/N rats. The macrophages were exposed to MG at concentrations of 0, 40, 80, 160 and 320 μg/ml. The effects of MG on the macrophages were examined by cell magnetometry, LDH assay and morphological observation. Results : In the cell magnetometry experiment, a significant delay of relaxation (the reduction of remanent magnetic field strength) was observed in the cells treated with 160 and 320 μg/ml of MG in a dose-dependent manner. A significant increase in LDH release was also observed in the cells with 160 and 320 μg/ml in a dose-dependent manner. Changes in the cytoskeleton were observed after exposure to MG, by immunofluorescent microscopy using an α-tubulin antibody. Conclusions : The cytotoxicity of MG on alveolar macrophages was demonstrated with cell magnetometry. The mechanism of the toxic effects of MG was related to cytoskeleton damage.
- 日本衛生学会の論文
著者
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AIZAWA Yoshiharu
Department of Preventive Medicine and Public Health, Kitasato University School of Medicine
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TSUNODA Masashi
Department of Preventive Medicine and Public Health, Kitasato University School of Medicine
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SATOH Toshihiko
Kitasato Clinical Research Center, Kitasato University School of Medicine
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KUDO Yuichiro
Department of Preventive Medicine and Public Health, Kitasato University School of Medicine
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SATOH Toshihiko
Department of Preventive Medicine and Public Health, Kitasato University School of Medicine
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WATANABE Mitsuyasu
Department of Preventive Medicine and Public Health, Kitasato University School of Medicine
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Kudo Yasushi
北里大学 医学部衛生学公衆衛学
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Kudo Yasushi
北里大学 医学部公衆学･衛生学
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Tsunoda Masashi
Department Of Hygiene Kitasato University School Of Medicine
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Sato Toshihiko
Kitasato Clinical Research Center Kitasato University School Of Medicine
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Sakai Yasuhiro
Department Of Anatomy School Of Medicine Kitasato University
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Sakai Yasuhiro
北里大学 医療系研究科労働衛生学
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Kudo Yasushi
Dep. Of Preventive Medicine And Public Health Kitasato Univ. School Of Medicine
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Kudo Yuichiro
Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine
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Kudo Yasushi
Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine
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NIITSUYA Masato
Department of Preventive Medicine and Public Health, Kitasato University School of Medicine
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KOTANI Makoto
Department of Electronics, Faculty of Engineering, Tokyo Denki University
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Aizawa Yoshiharu
Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine
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Satoh Toshihiko
Kitasato Clinical Research Center Kitasato University School Of Medicine
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Kotani M
Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine
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Tsunoda M
Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine
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SHINJI Hisako
Department of Preventive Medicine and Public Health, Kitasato University School of Medicine
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Shinji Hisako
Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine
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Watanabe Mituyasu
Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine
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Niitsuya Masato
Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine
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Niitsuya Masato
Department Of Internal Medicine And Pathology
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Kotani Makoto
Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine
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Sakai Yasuhiro
Department Of Anatomy Kitasato University School Of Medicine
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Sakai Yasuhiro
Department Of Anatomy Kitasato Universimty
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Watanabe Mitsuyasu
Dep. Of Preventive Medicine And Public Health Kitasato Univ. School Of Medicine
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Watanabe Mitsuyasu
Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine
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Satoh Toshihiko
Department Of Hygiene And Public Health Tokyo Women's Medical College
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Kudo Yuichiro
Department Of Health Care Management Kitasato University School Of Medicine
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Aizawa Yoshiharu
Department Of Occupational Health Graduate School Of Medical Sciences Kitasato University
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Kotani Makoto
Department Of Electronic Engineering Tokyo Denki University
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AIZAWA YOSHIHARU
Department of Internal Medicine, School of Medicine, Keio University
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