The Relation between Serum Cytokine Levels and Common Laboratory Tests in Healthy Japanese Males

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概要

• 論文の詳細を見る

• Objectives: Cytokines are critical regulatory molecules that circulate in blood at measurable levels. However, the epidemiology of serum cytokine levels in healthy populations is still limited, particularly for Japanese populations. The objective of this study was to examine the relation between serum cytokine levels and common laboratory tests in a healthy Japanese population. Methods: We studied serum levels of six cytokines (interleukin-4 (IL-4), IL-5, IL-6, IL-10, interferon-γ (IFN-γ), granulocyte-macrophage colony-stimulating factor (GM-CSF)) in a healthy Japanese population using a sensitive chemiluminescence ELISA (CL-ELISA). We examined the relations between serum cytokine levels and common laboratory tests using multiple regression analysis. We were particularly interested in potential relations between serum cytokine levels and C-reactive protein (CRP) in light of its relation to the risk of cardiovascular events. We also investigated the relation between cytokine levels, alcohol consumption and smoking. Results: After adjusting for the influence of other cytokines and laboratory tests, the serum level of IL-4 was associated with IL-5 and GM-CSF. In addition to IL-4, IL-5 was also associated with IL-10 and IFN-γ. IL-6 was associated with IL-10 and IFN-γ, and IL-10 and IFN-γ were associated with GM-CSF. CRP was significantly negatively associated with serum IL-4 level. IL-6 was weakly correlated with alcohol consumption level in this population. IL-5 among smokers tended to be lower than that among nonsmokers. Conclusions: Close relations among serum cytokine levels were observed in a healthy population. It is interesting that the level of IL-4, an anti-inflammatory cytokine, was inversely related to CRP level, suggested to be a marker of inflammation.

• 日本衛生学会の論文

著者

• TSUNODA Masashi

  Department of Preventive Medicine and Public Health, Kitasato University School of Medicine

• Tollerud David

  Department Of Environmental And Occupational Health Sciences School Of Public Health And Information

• Tollerud David

  米国

• Tollerud David

  Center For Environmental And Occupational Health School Of Public Health Mcp Hahnemann University

• Tollerud David

  University Of Pittsburgh Graduate School Of Public Health

• Tsunoda Masashi

  Department Of Hygiene Kitasato University School Of Medicine

• Tsunoda Humio

  Iwate Medical University

• TSUNODA Humio

  Professor emeritus, Iwate Medical University

• GUEVARRA Lucille

  Centerfor Environmental and Occupational Health, School of Public Health, MCP Hahnemann University

• Tsunoda M

  Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine

• Guevarra Lucille

  Department Of Pathology Joseph Stokes Research Center Of The Children's Hospital Of Philadelphi

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