Effect of Tributyltin Compound on N-methyl-D-aspartate (NMDA) Receptors in Brain of Preweanling Mice

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概要

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• Objective : The aim of this study was to investigate the effect of tributyltin (TBT) compound on N-methyl-D-aspartate (NMDA) receptors in the brains of preweanling mice. Methods : Pregnant ICR mice were exposed to TBT chloride at concentrations of 0, 15, and 50ppm in water. Male offspring were sacrificed at 1, 2 and 3 weeks after birth. Mouse brain membranes were prepared from cerebral cortices, and the specific binding of [^3H]MK-801 to an NMDA receptor was determined by radioligand binding assay. Results : The mean body weight of preweanling mice of the 50ppm dose group decreased by 17-25% (p<0.01) at 1, 2 and 3 weeks of age, compared with that of preweanling mice of the corresponding control group. The [^3H]MK-801 binding level significantly decreased (p<0.05) in the 15ppm F1 group at 1 week and in the 15ppm and 50ppm F1 groups at 3 weeks of age, compared with that in the corresponding control F1 group. Conclusions : The exposure to TBT via placenta and dam's milk seriously affected not only the growth of preweanling mice, but also the F1 cerebral NMDA receptors involved in memory and learning.

• 日本衛生学会の論文

著者

• TSUNODA Masashi

  Department of Preventive Medicine and Public Health, Kitasato University School of Medicine

• Konno Nobuhiro

  Koriyama Women's University And College

• Tsunoda Masashi

  Department Of Hygiene Kitasato University School Of Medicine

• KONISHI Yoshiko

  Division of Microbiology, National Institute of Health Sciences

• Konishi Yoshiko

  Division Of Microbiology National Institute Of Health Sciences

• Konno Nobuhiro

  Koriyama Women's Univ. And Coll. Koriyama Jpn

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