Behavior of Rock Wool in Rat Lungs after Exposure by Nasal Inhalation
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概要
- 論文の詳細を見る
To evaluate the safety of rock wool (RW) fibers, we examined the biopersistence of RW fibers in the lungs of rats, based on the changes of fiber number and fiber size in the length and width, in a nose-only inhalation exposure study. Twenty male Fischer 344 rats (6 to 10wk old) were exposed to RW fibers at a fiber concentration of 70.6 (20.4) fiber/m^3 and a dispersion density of 30.4 (6.6)mg/m^3 [arithmetic mean (SD)] continuously for 3h daily for 5 consecutive days. Five rats each were sacrificed shortly after exposure ended (baseline group) and at 1, 2, and 4wk after exposure, and their lung tissues were ashed by a low temperature plasma-asher. The numbers and sizes of fibers in the ash samples were determined using a phase contrast microscope and a computed image analyzer. The fiber numbers in the lungs at 4wk after exposure had significantly decreased from the baseline value, i. e. shortly after exposure (p<0.05). The half-lives of RW fibers calculated using the one-compartment model were 32d for total fibers and 10d for fibers longer than 20μm in length. Fiber number was 53.6% of the baseline at 4wk after exposure (baseline group=100%). Likewise, fiber sizes had significantly decreased at 4wk after exposure (p<0.05), probably because fibers had been dissolved in body fluid, phagocytosed by alveolar macrophages or discharged from the body by mucociliary movement. In future studies, it will be necessary to examine the carcinogenicity of RW fibers through long-term inhalation studies.
- 社団法人日本産業衛生学会の論文
著者
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AIZAWA Yoshiharu
Department of Preventive Medicine and Public Health, Kitasato University School of Medicine
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SATOH Toshihiko
Kitasato Clinical Research Center, Kitasato University School of Medicine
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KUDO Yuichiro
Department of Preventive Medicine and Public Health, Kitasato University School of Medicine
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SATOH Toshihiko
Department of Preventive Medicine and Public Health, Kitasato University School of Medicine
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Kudo Yasushi
北里大学 医学部公衆衛生学
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Kudo Yasushi
北里大学 医学部衛生学公衆衛学
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Kudo Yasushi
北里大学 医学部公衆学･衛生学
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相澤 好治
北里大学 医学部 衛生学公衆衛生学教室
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相澤 好治
Dep. Of Preventive Medicine And Public Health Kitasato Univ. School Of Medicine
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Sato Toshihiko
Kitasato Clinical Research Center Kitasato University School Of Medicine
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相澤 好治
北里大学・医・衛生公衛
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Kudo Yasushi
Dep. Of Preventive Medicine And Public Health Kitasato Univ. School Of Medicine
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Kudo Yuichiro
Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine
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Kudo Yasushi
Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine
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Aizawa Yoshiharu
Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine
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Satoh Toshihiko
Kitasato Clinical Research Center Kitasato University School Of Medicine
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KOHYAMA Norihiko
Faculty of Economy, Toyo University
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KONISHI Yoshihito
Japan Association for Working Environment Measurement
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Kohyama Norihiko
Faculty Of Economy Toyo University
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Aizawa Yoshifusa
Division Of Cardiology Hemotology And Endocrinology Niigata University Graduate School Of Medical An
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Satoh Toshihiko
Department Of Hygiene And Public Health Tokyo Women's Medical College
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Kudo Yuichiro
Department Of Health Care Management Kitasato University School Of Medicine
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Aizawa Yoshiharu
Department Of Occupational Health Graduate School Of Medical Sciences Kitasato University
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AIZAWA YOSHIHARU
Department of Internal Medicine, School of Medicine, Keio University
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