Behavior of New Type of Rock Wool (HT Wool) in Lungs after Exposure by Nasal Inhalation in Rats

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概要

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• Objectives : Previous types of rock wool has been recently replaced with high-temperature wool (HT wool). HT wool is characterized by a chemical composition with a higher concentration of Al_2O_3 and a lower concentration of SiO_2, lower biopersistence, and a higher melting point than previous types of rock wool. To evaluate the safety of HT wool, an asbestos substitute, we examined the biopersistence of HT wool in the lungs, based on changes in fiber count according to the length and fiber size (length and width), by performing a nose-only inhalation exposure study in rats. Methods : Male Fischer 344 rats were exposed to fibers at the target exposure concentration of 30mg/m^3 continuously for 3 hours daily for 5 consecutive days. Rats were sacrificed shortly after exposure, and 1, 2, and 4 weeks after exposure, and their lung tissues were incinerated at a low temperature. Then, fiber counts and sizes in the lungs were analyzed using a phase contrast microscope. Results : The fiber count in the lungs 4 weeks after exposure significantly decreased from the baseline value (shortly after exposure). The half-life of fibers calculated from the approximation curve was 34 days for all fibers and 11days for fibers longer than 20μm. Conclusions : Both the length and width significantly decreased 4 weeks after exposure, probably because fibers were ingested by alveolar macrophages, discharged to outside of the body by mucociliary movement, or lysed by body fluid. In future studies, it is necessary to examine the long-term persistence of fibers in the lungs.

• 日本衛生学会の論文

著者

• AIZAWA Yoshiharu

  Department of Preventive Medicine and Public Health, Kitasato University School of Medicine

• SATOH Toshihiko

  Kitasato Clinical Research Center, Kitasato University School of Medicine

• MIKI Takeo

  Department of Preventive Medicine and Public Health, Kitasato University School of Medicine

• KUDO Yuichiro

  Department of Preventive Medicine and Public Health, Kitasato University School of Medicine

• HOSOI Kaori

  Department of Preventive Medicine and Public Health, Kitasato University School of Medicine

• ISHIBASHI MIO

  Department of Preventive Medicine and Public Health, Kitasato University School of Medicine

• Kudo Yasushi

  北里大学 医学部公衆衛生学

• Kudo Yasushi

  北里大学 医学部衛生学公衆衛学

• Kudo Yasushi

  北里大学 医学部公衆学･衛生学

• SHIBATA KAORI

  Department of Internal Medicine, Doto Hospital, A Not-For-Profit Medical Foundation, N17, E14

• SATO Toshihiko

  Department of Internal Medicine, Osaka City General Hospital

• 相澤 好治

  Dep. Of Preventive Medicine And Public Health Kitasato Univ. School Of Medicine

• Miki Takeo

  Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine

• Sato Toshihiko

  Kitasato Clinical Research Center Kitasato University School Of Medicine

• Kudo Yasushi

  Dep. Of Preventive Medicine And Public Health Kitasato Univ. School Of Medicine

• Kudo Yuichiro

  Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine

• Kudo Yasushi

  Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine

• Aizawa Yoshiharu

  Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine

• Sato Toshihiko

  Department Of Cardiology Tokyo Women's Medical University

• Satoh Toshihiko

  Kitasato Clinical Research Center Kitasato University School Of Medicine

• KOHYAMA Norihiko

  Faculty of Economy, Toyo University

• Sakabe Kou

  Dep. Of Public Health And Molecular Toxicology Kitasato Univ. School Of Pharmaceutical Sciences

• Hosoi Kaori

  Department Of Preventive Medicine And Public Health Kitasato University School Of Medicine

• Hosoi Kaori

  Department Of Pediatrics Graduate School Of Medicine Gifu University

• Shibata Kaori

  Department Of Human Structure And Function Tokai University School Of Medicine

• Kohyama Norihiko

  Faculty Of Economy Toyo University

• Kudo Yuichiro

  Department Of Health Care Management Kitasato University School Of Medicine

• Aizawa Yoshiharu

  Department Of Occupational Health Graduate School Of Medical Sciences Kitasato University

• AIZAWA YOSHIHARU

  Department of Internal Medicine, School of Medicine, Keio University

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