Practical Stereoselective Syntheses of All Four Stereoisomers of Coronamic Acid (2-Ethyl-1-aminocyclopropane-1-carboxylic acid)
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概要
- 論文の詳細を見る
All four stereoisomers of coronamic acid were synthesized from both enantiomers of 1, 2-butanediol. Cyclopropanation of cyclic sulfate with the dibenzyl malonate anion gave cyclopropane dibenzyl ester in a quantitative yield. Transformation into a protected amino acid was achieved by stereoselective hydrolysis and Curtius rearrangement as the key steps. Saponification and subsequent acidic hydrolysis in one pot and ion exchange gave a free amino acid in a high yield.
- 社団法人日本農芸化学会の論文
- 1995-03-23
著者
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TOSHIMA Hiroaki
Department of Bioresource Science, College of Agriculture, Ibaraki University
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ICHIHARA Akitami
Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University
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Toshima Hiroaki
Department Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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Ichihara Akitami
Department Of Applied Bioscience Graduate School Of Agriculture Hokkaido University
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