Hemodynamic Effects of Nitroprusside on Cardiovascular System : SYMPOSIUM ON HEART FAILURE AND VASODILATOR THERAPY
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概要
- 論文の詳細を見る
The effects of nitroprusside (NP) on hemodynamics, especially on venous flow velocity of the inferior vena cava (IVC) were evaluated in 20 remote myocardial infarction patients. NP was given begining at 10 μg/min, with subsequent increments of 10 μg/min every 5 minutes until the systolic blood pressure was reduced to about 30 mmHg. Pressure was measured by a catheter-tip micromanometer. Flow velocity of IVC was measured by a catheter-tip flow velocity probe. NP significantly decreased left ventricular systolic pressure, left ventricular end-diastolic pressure, mean aortic pressure, right ventricular systolic pressure, right ventricular end-diastolic pressure, mean pulmonary arterial pressure, mean pulmonary capillary wedge pressure, systemic vascular resistance index (SVRI) and left ventricular volume. Cardiac index (CI) was unchanged and stroke volume index was decreased. IVC pressure was unchanged, while right atrial (RA) pressure decreased. Subsequently, the pressure difference between IVC and RA increased significantly. The amplitude of IVC flow velocity decreased significantly. Twenty patients were classified into two groups according to whether or not the CI increased by NP. CI increased in 9 patients (group I) and decreased in 11 patients (group D). Compared to group D, control CI and the slope of end-systolic pressure-volume relation were less and the difference between IVC pressure and RA pressure was greater in group I. The patients with higher control SVRI had greater increase in CI during NP. In our study, the greater the depression of cardiac performance and the higher the SVRI, the greater the improvement of left ventricular pumping function during NP.
- 社団法人日本循環器学会の論文
- 1984-04-20
著者
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Miura Toshiro
The Second Department Of Internal Medicine Yamaguchi University Hospital
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Kawamura K
Department Of Internal Medicine (iii) Osaka Medical College
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Katayama Kazuhiro
Second Department Of Internal Medicine Yamaguchi University School Of Medicine
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Katayama Kazuhiro
The Second Department of Interial Medicine, Yamaguchi University School of Medicine
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KUSUKAWA Reizo
The second Department of Internal Medicine, Yamaguchi University School of Medicine
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MATSUDA YASUO
The Second Department of Internal Medicine, University of Yamaguchi
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Fujii Takashi
The Second Department of Internal Medicine, Yamaguchi University School of Medicine
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Kohno Michihiro
The Second Department of Internal Medicine, Yamaguchi University School of Medicine
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KUMADA TOSHIAKI
The Second Department of Internal Medicine, Yamaguchi University School of Medicine
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Kumada Toshiaki
The Third Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Kumada Toshiaki
The 3rd Medical Clinic Kyoto University Hospital
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Konishi Mitsuaki
Second Division Department Of Internal Medicine Yamaguchi University
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Moritani Koshiro
Second Dept. Of Internal Med. Yamaguchi University
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Yonezawa Fumio
Department Of Internal Medicine Yamaguchi University School Of Medicine
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Kohno Michihiro
Division Of Cardiovascular Medicine Department Of Medical Bioregulation Yamaguchi University Graduat
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Kohno Michihiro
Second Division Department Of Internal Medicine Yamaguchi University
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Kusukawa Reizo
The Second Department Of Internal Medicine Yamaguchi University School Of Medicine
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Yoshino Fumio
The Second Division of Internal Medicine, Yamaguchi University School of Medicine
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Ogawa Hiroshi
The Second Division of Internal Medicine, Yamaguchi University School of Medicine
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Kumada Toshiaki
The 2nd Department Of Internal Medicine Faculty Of Medicine Yamaguchi University
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Moritani Kohshiro
The Second Division, Department of Internal Medicine, Yamaguchi University School of Medicine
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Kusukawa Reizo
Department Of Cardiology Tenri Hospilal
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Fujii Takasi
The Second Depertment Of Internal Medicine
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Kumada Toshiaki
The Second Department Of Internal Medicine Yamaguchi University School Of Medicine
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Yoshino F.
Second Department Of Internal Medicine Yamaguchi University School Of Medicine
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Yonezawa F.
Second Department Of Internal Medicine Yamaguchi University School Of Medicine
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