Effect of Intravenous Magnesium Sulfate on Cardiac Arrhythmias in Critically Ill Patients with Low Serum Ionized Magnesium
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概要
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Magnesium affects cardiac function, although until the recent development of a new ion-selective electrode no method existed for measuring the physiologically active form of magnesium, free ions (iMg^<2+>), in the blood. We investigated the antiarrhythmic effect of magnesium sulfate administered to critically ill patients with cardiac arrhythmias and reduced iMg^<2+> as determined using the ion-selective electrode. Eight patients with a low iMg^<2+> level (less than 0.40 mmol/L) were given intravenous magnesium sulfate (group L). Magnesium sulfate was also administered to patients with a normal iMg^<2+> level (more than 0.40 mmol/L) but who did not respond to conventional antiarrhythmic drugs (group N). Intravenous magnesium sulfate significantly increased the iMg^<2+> level in patients in group L from 0.35±0.06 mmol/L (mean ±SD) to 0.54±0.09 mmol/L (p<0.01), and had an antiarrhythmic effect in 7 of the 8 patients (88%). However, in group N patients, intravenous magnesium sulfate had an antiarrhythmic effect in only 1 of the 6 patients (17%) (p<0.05 vs group L). These results suggest that intravenous magnesium sulfate may be effective in the acute management of cardiac arrhythmias in patients with a low serum iMg^<2+> level.
- 社団法人日本循環器学会の論文
- 1996-10-20
著者
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Miura Toshiro
The Second Department Of Internal Medicine Yamaguchi University Hospital
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SOEJIMA Yoshiyuki
Total Care Unit and Intensive Care Unit, Yamaguchi University, School of Medicine
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TATEISHI Akio
Total Care Unit and Intensive Care Unit, Yamaguchi University, School of Medicine
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Nakashima K
The Intensive Care Unit Yamaguchi University School Medicine
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Tateishi A
Total Care Unit Yamaguchi University School Of Medicine
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Kasaoka Shunji
Critical Care Medical Center, Yamaguchi University Hospital
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Tsuruta Ryosuke
Critical Care Medical Center, Yamaguchi University Hospital
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Nakashima Ken
Critical Care Medical Center, Yamaguchi University Hospital
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Soejima Yoshiyuki
Critical Care Medical Center, Yamaguchi University Hospital
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Sadamitsu Daikai
Department of Emergency Medicine, Yamaguchi University Hospital
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Tateishi Akio
Critical Care Medical Center, Yamaguchi University Hospital
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Maekawa Tsuyoshi
Department of Emergency Medicine, Yamaguchi University Hospital
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MAEKAWA TSUYOSHI
Advanced Medical Emergency And Critical Care Center, Yamaguchi University Hospital
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Maekawa Tsuyoshi
Advanced Medical Emergency And Critical Care Center Yamaguchi University Hospital
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Maekawa Tsuyoshi
Department Of Critical Care And Emergency Medicine School Of Medicine Yamaguchi University
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Tateishi Aiko
Total Care Unit Yamaguchi University School Of Medicine
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Tsuruta Ryosuke
Advanced Medical Emergency And Critical Care Center Yamaguchi University Hospital
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Soejima Yoshiyuki
Total Care Unit And Intensive Care Unit Yamaguchi University School Of Medicine
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Sadamitsu Daikai
Medical Emergency & Critical Care Center Yamaguchi University Hospital
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