Effect of Beta-Blocker Treatment in Dilated Cardiomyopathy With Bradyarrhythmias
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概要
- 論文の詳細を見る
This study was performed to evaluate whether beta-blocker therapy was effective in patients with nonischemic dilated cardiomyopathy(DCM)and bradyarrhythmias supported by pacemaker implantation. Beta-blocker therapy is useful for some patients with DCM, especially those with rapid heart rate or residual nonfibrotic myocardium in the left ventricle, but no data exist on whether beta-blocker therapy is useful in patients with DCM and bradyarrhythmias. The effectiveness of beta-blocker therapy was prospectively evaluated in patients with DCM and bradyarrhythmias supported by pacemaker implantation and compared with those without these arrhythmias. Beta-blocker therapy was started in 63 patients(45 men, 18 women, aged 11-83 years)with DCM, in whom 7 had bradyarrhythmias and 56 did not. These bradyarrhythmias were atrioventricular block, sick sinus syndrome and atrial fibrillation with slow heart rate. Of the 56 patients without bradyarrhythmias, 42(75%)(group 1)responded to beta-blocker therapy, but 5 of the 7 with bradyarrhythmias(71%)(group 2)also responded. Left ventricular end-diastolic dimension was reduced(6.5±0.6 cm to 5.6±0.5 cm ; p<0.0001 in group 1 ; 6.6±0.8 cm to 5.5±0.2 cm ; p<0.02 in group 2)and left ventricular fractional shortening was improved(13±4% to 27±7% ; p<0.0001 in group 1 ; 12±4% to 29±10% ; p<0.05, in group 2)to the same degree in both groups. These results indicate that beta-blocker therapy for DCM is effective not only in patients without bradyarrhythmias but also in those with bradyarrhythmias supported with pacemaker implantation.
- 社団法人日本循環器学会の論文
- 1998-09-20
著者
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Suwa M
Hokusetsu General Hospital
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Suwa Michihiro
The Third Division, Department of Internal Medicine
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Ito Takahide
The Third Division, Department of Internal Medicine, Osaka Medical College
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Kobashi Ayaka
The Third Division,Department of Internal Medicine,Osaka Medical Colleg
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Ito Takahide
Hayama Heart Center
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Kawamura K
Department Of Internal Medicine (iii) Osaka Medical College
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Kawamura Keishiro
Department Of Cardiology Sakakibara Heart Institute
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Kawamura Keishiro
大阪医科大学 内科学iii
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Kawamura Keishiro
The Third Division Department Of Internal Medicine Osaka Medical College
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Kawamura Keishiro
The Third Division Internal Medicine Osaka College
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Kawamura Keishiro
The Third Divisin Department Of Internal Medicine Osaka Medical College
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Hirota Yuzo
The Third Division, Department of Internal Medicine, Osaka Medical College
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Otake Yoshiaki
The Third Division, Department of Internal Medicine, Osaka Medical College
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Hirota Yuzo
The Third Division Department Of Internal Medicine Osaka Medical College
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Hirota Yuzo
Department Of Thoracic Surgery Osaka Medical College
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Hirota Yuzo
The Third Division Department Of Internal Medicine Osaka Medical College Takatsuki
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Otake Yoshiaki
The Third Division Department Of Internal Medicine Osaka Medical College
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Suwa Michihiro
Dept. Of Intern. Med. Osaka Medical Colledge.
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Suwa Michihiro
3rd Division Department Of Internal Medicine Osaka Medical College
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Suwa Michihiro
Third Department Of Internal Medicine Osaka Medical College
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Ito Takahide
The Third Division Department Of Internal Medicine Osaka Medical College
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Kobashi Ayaka
The Third Division Department Of Internal Medicine Osaka Medical Colleg
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Suwa Michihiro
The Third Division Department Of Internal Medicine Osaka Medical College
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Kawamura Keishiro
Department Of Internal Medicine (iii) Osaka Medical College
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Hirota Yuzo
The Third Department Of Internal Medicine Osaka Medical College
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Suwa Michihiro
大阪医科大学
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Kawamura Keishiro
3rd Div. Dept. Intern. Med. Osaka Medical College
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Kawamura Keishiro
3rd Div. Dept. Of Intern. Med. Kyoto Univ. Hosp.
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Ito Takahide
The Third Department Of Internal Medicine Osaka Medical College
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Kawamura Keishiro
The 3rd Div. Dept.of Int.med. Osaka Medical College
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Kawamura Keishiro
The Third Department Of Internal Medicine Osaka Medical College
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Katayama Kazuhiro
2nd Dept. Of Internal Med. Yamaguchi University
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