Effect of Right Ventricular Volume Overload on Left Ventricular Diastolic Function in Patients With Atrial Septal Defect
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概要
- 論文の詳細を見る
This study was undertaken to investigate the effect of chronic right ventricular (RV) volume overload on left ventricular (LV) diastolic function. Twelve patients with atrial septal defect and 7 age-matched normal controls were examined. Patients with atrial septal defect were divided into 2 groups based on their Qp/Qs values (ASD1:Qp/Qs≤3, n=7;ASD2:Qp/Qs>3, n=5). The LV volume curve and its first derivative were derived by a frame-by-frame analysis of the left ventriculogram. The peak filling rate was defined by the peak positive first derivative of the LV volume curve. We measured the time constant, isovolumetric relaxation time, stiffness constant and compliance at LV end-diastole. The time constant was significantly prolonged in the ASD2 group compared with the controls, and the isovolumtetric relaxation time in both atrial septal defect froups was also prolonged compared with the controls. The peak filling rate, which was normalized by end-diastolic volume, was lower in the ASD2 group than in the controls. Although the stiffness constant and the compliance at LV end-diastole in the controls were not significantly different from those in the atrial septal defect group, an upward and leftward displacement of the left ventricular pressure-volume curve was observed in patients with atrial septal defect. Moreover, a significant correlation(r=0.78, p<0.01) was observed between the time constant and RV end-diastolic pressure. Thus, these results suggest that chronic RV volume overload affects left ventricular diastolic function.
- 社団法人日本循環器学会の論文
- 1996-09-20
著者
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Hiro Takafumi
Departments Of Internal Medicine And Cardiology Osaka City University Graduate School Of Medicine
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Yano Masafumi
Department Of Medicine And Clinical Science Division Of Cardiology Yamaguchi University Graduate Sch
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Miura Toshiro
Department Of Medicine And Clinical Science Yamaguchi University Graduate School Of Medicine
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Miura Toshiro
The Second Department Of Internal Medicine Yamaguchi University Hospital
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Kawamura K
Department Of Internal Medicine (iii) Osaka Medical College
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MATSUZAKI Masunori
the Second Department of Internal Medicine, Yamaguchi University School of Medicine
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Katayama Kazuhiro
Department Of Internal Medicine (iii) Osaka Medical College
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Katayama Kazuhiro
Second Department Of Internal Medicine Yamaguchi University School Of Medicine
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Katayama Kazuhiro
The Second Department of Interial Medicine, Yamaguchi University School of Medicine
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Miura Toshiro
Second Department Of Internal Medicine Yamaguchi University School Of Mediciney
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Fujii Takashi
The Second Department of Internal Medicine, Yamaguchi University School of Medicine
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Satoh Akira
The Second Department of Internal Medicine, Yamaguchi University School of Medicine
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Hiro Takafumi
The Second Department of Internal Medicine, Yamaguchi University School of Medicine
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Yano Masafumi
The Second Department of Internal Medicine, Yamaguchi University School of Medicine
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Kohno Michihiro
The Second Department of Internal Medicine, Yamaguchi University School of Medicine
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Kohno Michihiro
Division Of Cardiovascular Medicine Department Of Medical Bioregulation Yamaguchi University Graduat
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Kohno Michihiro
Second Division Department Of Internal Medicine Yamaguchi University
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Matsuzaki Masunori
The Second Department Of Internal Medicine University Of Yamaguchi
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Miyazaki Tsuyoshi
Department Of Rheumatology Sagamihara National Hospital National Hospital Organization (nho)
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Fujii Takasi
The Second Depertment Of Internal Medicine
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Satoh Akira
Second Department Of Internal Medicine Yamaguchi University School Of Medicine
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