Acute Effects of Diltiazem on Regional Left Ventricular Diastolic Filling Dynamics in Patients With Hypertrophic Cardiomyopathy as Assessed by Color Kinesis
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概要
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Background The effect of calcium antagonists on regional left ventricular (LV) filling dynamics in patients with hypertrophic cardiomyopathy (HCM) is not well known, so the present study evaluated the results of echocardiography with color kinesis (CK) analysis during diltiazem infusion. Methods and Results Nineteen patients (16 men, 3 women; mean age 55±15 years) underwent echocardiography with CK analysis during intravenous diltiazem (10mg/2min). Using the quantitative CK software the LV short-axis image was divided into 6 segments and the percent endocardial expansion at the early, mid- and late-diastolic filling time was averaged for all segments, with the standard deviation of the mean used as an index of diastolic asynchrony (asynchrony index). The regional mean filling time was also measured for the corresponding segments. As global diastolic parameters, the global filling time, peak filling rate, and the time-to-peak filling were calculated. After the administration of diltiazem, the asynchrony index was decreased for all three diastolic filling times. Diltiazem shortened the mean filling time overall, especially in the posterior and lateral wall segments. These findings were associated with significant improvement in the CK-derived global diastolic parameters. Conclusions Diltiazam has a favorable effect on LV diastolic asynchrony, which may account for the acute changes in global LV relaxation.
- 社団法人日本循環器学会の論文
- 2004-10-20
著者
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Suwa M
Hokusetsu General Hospital
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Suwa Michihiro
The Third Division, Department of Internal Medicine
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Kitaura Yasushi
The Third Division, Department of Internal Medicine
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Tonari Satoko
Third Department of Medicine, Osaka Medical College
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Ito Takahide
The Third Division, Department of Internal Medicine, Osaka Medical College
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Imai Makoto
The Third Division, Department of Internal Medicine, Osaka Medical College
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Hozumi Tomomi
The Third Division, Department of Internal Medicine, Osaka Medical College
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Tonari Satoko
The Third Division, Department of Internal Medicine, Osaka Medical College
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Ito Takahide
Hayama Heart Center
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Suwa Michihiro
Dept. Of Intern. Med. Osaka Medical Colledge.
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Suwa Michihiro
3rd Division Department Of Internal Medicine Osaka Medical College
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Suwa Michihiro
Third Department Of Internal Medicine Osaka Medical College
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Ito Takahide
The Third Division Department Of Internal Medicine Osaka Medical College
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Hozumi Tomomi
Third Division Department Of Internal Medicine Osaka Medical College
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Suwa Michihiro
Iii Div Osaka Med. College
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Suwa Michihiro
The Third Division Department Of Internal Medicine Osaka Medical College
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Ito Takahide
Third Department Of Internal Medicine Osaka Medical College
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Imai Makoto
The Third Division Department Of Internal Medicine Osaka Medical College
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Tonari Satoko
Third Department Of Medicine Osaka Medical College
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Suwa Michihiro
大阪医科大学
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Tonari Satoko
The Third Department Of Internal Medicine Osaka Medical College
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Kitaura Yasushi
The Third Department Of Internal Medicine Osaka Medical College
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Kitaura Yasushi
Laboratory Of Pharmacotherapy Osaka University Of Pharmaceutical Sciences
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Ito Takahide
The Third Department Of Internal Medicine Osaka Medical College
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Suwa Michihiro
3rd Div. Dept. Intern. Med. Osaka Medical College
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