Comparson of the Therapeutic Effects of the Beta-Blocking Agent Bisoprolol and the Calcium-Blocking Agent Diltiazem in Patients With Heart Failure Due to Dilated Cardiomyopathy
スポンサーリンク
概要
- 論文の詳細を見る
Beta-blocking agents reduce mortality and improve symptoms in patients with dilated cardiomyopathy (DCM). There have been reports that diltiazem, a calcium-blocking agent, is also effective in such patients. We prospectively compared the effects of the beta-blocking agent bisoprolol with those of the calcium-blocking agent diltiazem in 18 patients (11 males and 7 females, age 14 to 68) with DCM. The 18 patients (10 in New York Heart Association functional class III and 8 in class IV) were randomly assigned to 2 groups. Bisoprolol was administered as the first grug in 10 patients and diltiazem was administered in 8. Cross-over to bisoprolol was also performed in 3 patients. At the end of the study, among the 13 patients who had been given bisoprolol, 9 showed a good response (efficacy rate: 69%). In contrast, only 3 of the 8 patients who received diltiazem showed a good response (efficacy rate: 37.5%). Among the patients in NYHA class III, all 7 (100%) who were treated with bisoprolol responded but only 2 of 4 (50%) treated with diltiazem responded (p<0.05). Among the patients in class IV, 2 of 6 (33%) responded to bisoprolol and 1 of 4 (25%) responted to diltiazem (not significant). These result suggest that diltiazem, like bisoprolol, has beneficial effect in patients with DCM, with a greater effect in class III patients. However, we conclude that diltiazem shold usually be used as a second choice to improve heart failure in DCM, and as the first medication only in those with contraindications to beta-blocking agents.
- 社団法人日本循環器学会の論文
- 1996-09-20
著者
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Suwa M
Hokusetsu General Hospital
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Suwa Michihiro
The Third Division, Department of Internal Medicine
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Ito Takahide
The Third Division, Department of Internal Medicine, Osaka Medical College
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Ito Takahide
Hayama Heart Center
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Kawamura Keishiro
Department Of Cardiology Sakakibara Heart Institute
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Kawamura Keishiro
大阪医科大学 内科学iii
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Kawamura Keishiro
The Third Division Department Of Internal Medicine Osaka Medical College
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Kawamura Keishiro
The Third Division Internal Medicine Osaka College
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Kawamura Keishiro
The Third Divisin Department Of Internal Medicine Osaka Medical College
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Hirota Yuzo
The Third Division, Department of Internal Medicine, Osaka Medical College
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Otake Yoshiaki
The Third Division, Department of Internal Medicine, Osaka Medical College
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Moriguchi Ayaka
Third Division, Department of Internal Medicine, Osaka Medical College
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Moriguchi Ayaka
The third Division, Department of Internal Medicine, Osaka Medical College
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Hirota Yuzo
The Third Division Department Of Internal Medicine Osaka Medical College
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Hirota Yuzo
Department Of Thoracic Surgery Osaka Medical College
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Hirota Yuzo
The Third Division Department Of Internal Medicine Osaka Medical College Takatsuki
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Moriguchi Ayaka
Third Division Department Of Internal Medicine Osaka Medical College
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Otake Yoshiaki
The Third Division Department Of Internal Medicine Osaka Medical College
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Suwa Michihiro
Dept. Of Intern. Med. Osaka Medical Colledge.
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Suwa Michihiro
3rd Division Department Of Internal Medicine Osaka Medical College
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Suwa Michihiro
Third Department Of Internal Medicine Osaka Medical College
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Ito Takahide
The Third Division Department Of Internal Medicine Osaka Medical College
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Suwa Michihiro
The Third Division Department Of Internal Medicine Osaka Medical College
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Kawamura Keishiro
Department Of Internal Medicine (iii) Osaka Medical College
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Hirota Yuzo
The Third Department Of Internal Medicine Osaka Medical College
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Suwa Michihiro
大阪医科大学
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Kawamura Keishiro
3rd Div. Dept. Intern. Med. Osaka Medical College
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Kawamura Keishiro
3rd Div. Dept. Of Intern. Med. Kyoto Univ. Hosp.
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Ito Takahide
The Third Department Of Internal Medicine Osaka Medical College
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Kawamura Keishiro
The 3rd Div. Dept.of Int.med. Osaka Medical College
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Kawamura Keishiro
The Third Department Of Internal Medicine Osaka Medical College
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