LONG-TERM α_1 BLOCKADE DOES NOT REVERSE CARDIAC HYPERTROPHY IN SPONTANEOUSLY HYPERTENSIVE RATS

概要

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Not all antihypertensive drugs induce regression of left ventricular (LV) hypertrophy in hypertension, although they may equally lower blood pressure. The effects of α_1-blockers on regression have been inconsistent. In this study, bunazosin, a selectiveα_1-blocker, (15 mg/kg/day in food) was given to male spontaneously hypertensive rats (SHR) from 15 to 35 weeks of age to evaluate its effects on cardiac hypertrophy, hemodynamics, and neurohumoral factors. Age- and sex-matched SHR served as controls. LV function and cardiac output were determined by a micromanometer and thermodilution, respectiveiy. Bunazosin significantly decreased blood pressure in conscious rats (from 209 to 192 mmHg, p<0.01) but did not reduce LV mass. Heart rate, LV end-diastolic pressure, dp/dt_<max>, and cardiac output were similar in the 2 groups. Plasma renin activity was unaltered but plasma norepinephrine levels were higher in the treated rats (p<0.05). Thus, bunazosin produced a significant relative reduction of blood pressure but did not reverse LV hypertrophy in SHR. Inadequate afterload reduction (8%) due to severe hypertension (>200 mmHg) may explain the absence of regression. The rise of plasma norepinephrine levels may also offset the beneficial effects of bunazosin.
社団法人日本循環器学会の論文
1993-08-20