Effects of Nicorandil on Left Ventricular Systolic and Diastolic Function in Patients with Hypertrophic Cardiomyopathy
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概要
- 論文の詳細を見る
Various evidence suggest that myocardial ischemia is a major factor in the progression of hypertrophic cardiomyopathy (HCM). In this study, we investigated the effects of nicorandil on left ventricular (LV) systolic and diastolic function in 12 symptomatic patients with HCM using echocardiography and radionuclide angiography. Nicorandil (6 mg), when administered intravenously, produced no significant changes in any parameter, including LV filling dynamics. However, accelerated LV peak early filling velocity (0.51±0.13 to 0.59±0.14 m/sec, p<0.01), and reduced peak velocity in atrial contraction (0.54±0.17 to 0.50±0.15 m/sec, p<0.05) were observed by Doppler echocardiography after 4 weeks of oral administration of 10 mg nicorandil 3 times daily. This oral administration did not affect heart rate, blood pressure, LV outflow gradient, or LV systolic function. The same favorable results were observed in a wall motion analysis with radionuclide angiography: peak filling rate (PFR) in global LV (3.21±0.76 to 3.52±0.87 end-diastolic volume (EDV)/sec, p<0.02), and apical (4.73±1.18 to 5.42±1.55 EDV/sec, p<0.01) and lateral (4.78±1.60 to 5.52±1.51 EDV/sec, p<0.05) segments was increased, and the time to peak filling rate (TPF) in septal (245±31 to 203±40 msec, p<0.01) and lateral (222±54 to 193±34 msec, p<0.05) segments was reduced. These findings indicate that nicorandil has beneficial effects on LV diastolic function in HCM. These favorable effects may be due to the improvement of subendocardial ischemia.
- 社団法人日本循環器学会の論文
- 1995-02-20
著者
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Suwa M
Hokusetsu General Hospital
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ITO Takahide
Third Department of Internal Medicine, Osaka Medical College
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Suwa Michihiro
Third Department of Medicine, Osaka Medical College
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Ito Takahide
Hayama Heart Center
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Kawamura Keishiro
大阪医科大学 内科学iii
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Hirota Yuzo
The Third Division, Department of Internal Medicine, Osaka Medical College
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Hirota Yuzo
Third Division, Department of Internal Medicine, Osaka Medical College
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Kawamura Keishiro
Third Division, Department of Internal Medicine, Osaka Medical College
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Otake Yoshiaki
Third Division, Department of Internal Medicine, Osaka Medical College
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Hirota Yuzo
The Third Division Department Of Internal Medicine Osaka Medical College
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Hirota Yuzo
Department Of Thoracic Surgery Osaka Medical College
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Hirota Yuzo
Third Division Department Of Internal Medicine
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Hirota Yuzo
The Third Division Department Of Internal Medicine Osaka Medical College Takatsuki
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Otake Yoshiaki
The Third Division Department Of Internal Medicine Osaka Medical College
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Suwa Michihiro
Dept. Of Intern. Med. Osaka Medical Colledge.
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Suwa Michihiro
3rd Division Department Of Internal Medicine Osaka Medical College
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Suwa Michihiro
Third Department Of Internal Medicine Osaka Medical College
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Kawamura Keishiro
Department Of Internal Medicine (iii) Osaka Medical College
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Ito Takahide
Third Department Of Internal Medicine Osaka Medical College
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Kusukawa Jyunya
Third Division, Department of Internal Medicine, Osaka Medical College
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Kusukawa Jyunya
Third Division Department Of Internal Medicine Osaka Medical College
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Kawamura Keishiro
Third Department Of Internal Medicine Osaka Medical College
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Suwa Michihiro
大阪医科大学
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Kawamura Keishiro
3rd Div. Dept. Intern. Med. Osaka Medical College
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Kawamura Keishiro
The 3rd Div. Dept.of Int.med. Osaka Medical College
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